复方莫西沙星滴耳液的主要药效学  

Study on main pharmacodynamics of compound moxifloxacin ear drops

作　　者：黄道秋[1] 岳书华[1] 

机构地区：[1]重庆三峡中心医院药剂科,重庆404000

出　　处：《中国医院药学杂志》2009年第15期1270-1273,共4页Chinese Journal of Hospital Pharmacy

基　　金：重庆万州区科技攻关项目(编号:2007302)

摘　　要：目的:研究复方莫西沙星滴耳液体内外的抗菌作用及其对肉芽肿生长的影响。方法:采用试管双倍稀释法测定MIC50。将家兔随机分为模型组、阳性对照组和高、中、低剂量治疗组,每组10只,以金黄色葡萄球菌、铜绿假单胞菌和大肠埃希菌的混合菌液感染家兔,建立中耳炎模型,模型组不用任何药物治疗,阳性对照组滴注氧氟沙星滴耳液,每次每耳0.5mL,tid,高、中、低剂量组家兔每次每耳分别给予复方莫西沙星滴耳液0.8,0.5,0.2mL,tid,治疗1周后,进行疗效评价。将复方莫西沙星滴耳液外涂于小鼠肉芽肿局部,连续用药1周,比较其与氧氟沙星滴耳液和氢化可的松溶液的疗效差异。结果:复方莫西沙星滴耳液对金黄色葡萄球菌、铜绿假单胞菌、克雷伯菌、变形杆菌的MIC50分别为0.09,1.46,0.09,0.73μg.L-1。高、中剂量组显效率与阳性对照组相比,差异有显著性(P<0.05)。复方莫西沙星滴耳液对小鼠肉芽肿有明显抑制作用,与氢化可的松相当(P>0.05),与氧氟沙星滴耳液相比差异有显著性(P<0.05)。结论:复方莫西沙星滴耳液是治疗敏感菌所致中耳炎的有效药物,有良好的应用价值。OBJECTIVE To investigate the in vivo and in vitro antibacterial activity of compound moxifloxacin ear drops and its inhibitory effect on the growth of granuloma. METHODS MIC50 were detected by double dilution method. The rabbits were randomized into 5 groups, model control group, positive control group, high, middle and low dose groups, 10 rabbits each. Rabbits except in normal control group were induced as otitis media models by injection of a mixed solution of Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli. The rabbits in model control group received no treatment, while positive control group was given with 0. 5 mL ofloxacin ear drops each ear, 3 times per day. The high, middle and low dose groups were treated with 0. 8,0. 5 and 0. 2 mL of compound moxifloxacin ear drops, 3 times per day, respectively. The therapeutic efficacy was evaluated after one-week treatment. Compound moxifloxacin ear drops were applied to granuloma in mice, then its efficacy was compared with that of ofloxacin ear drops and hydrocortisone solution after one week. RESULTS MIC50 of compound moxifloxacin ear drops to staphylococcus aureus, pseudomonas aeruginosa, klebsiella pneumoniae and bacillus proteus were 0. 09, 1.46,0. 09 and 0. 73μg·L7-1 , respectively. The effective rate of high and middle dose groups were significantly different with that of positive control group（P〈0. 05）. Compound moxifloxacin ear drops exhibited remarkable inhibitory effect on the growth of granuloma in mice,which is similar to the effect of hydrocortisone（P〉0. 05） and significantly better than that of ofloxacin ear drops（P〈0. 05）. CONCLUSION Compound moxifloxacin ear drops is effective in the treatment of otitis media induced by pathogenic bacteria so that it has good clinical application.

关 键 词：莫西沙星 滴耳液 药效学 中耳炎 动物模型 

分 类 号：R961[医药卫生—药理学]