地诺前列酮栓用于晚期妊娠合并羊水过少68例临床分析  

Clinical analysis of new prostaglandin E2(PGE2)suppository for induction of late pregnancy with olighydramnios

作　　者：何海珍[1] 张红萍[1] 王叶红[1] 叶笑梅[1] 鲁意[1] 

机构地区：[1]温州市第三人民医院温州市妇幼保健院,浙江温州325000

出　　处：《中国医院药学杂志》2009年第15期1307-1309,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探讨地诺前列酮栓用于晚期妊娠合并羊水过少引产的临床优越性。方法:将68例晚期妊娠合并羊水过少、宫颈Bishop评分平均4.8分、无阴道分娩禁忌证的单胎头位初产妇随机分为2组:34例(宫颈Bishop评分<6分)将地诺前列酮栓(普贝生)一枚置于阴道后穹窿作为实验组;34例(宫颈Bishop评分>6分)给予催产素静滴作为对照,比较2组产妇用药前及用药后12h的宫颈Bishop评分、用药到临产及分娩所需时间、胎心、羊水变化情况、分娩方式、成功率,产后出血情况、对胎儿及新生儿的影响。结果:试验组用药后促宫颈成熟效果和阴道分娩率均优于对照组;临产时间及产程短于对照组;胎心异常、羊水污染发生率、产后出血量及2组新生儿结局差异无显著性。结论:普贝生促宫颈成熟较催产素更安全、有效、方便,引产成功率高,可明显降低剖宫产率。OBJECTIVE To observe the clinical superiority of new prostaglandin E2 （PGE2） Suppository used for induction of late pregnancy with oligohydramnios. METHODS The 68 nulliparous single late pregnant women with oligohydramnios, proper fetal position, the cervical Bishop scoring average 4. 8, without any vaginal delivery contraindication were divided into test group, in which one piece of Propess was put into the vaginal posterior fornix; and control group, in which the oxytoein was used intravascularly. The cervical maturity （by Bishop scoring） before this management and 12 hours after treatment, the time to labor starting, the time to delivery, viginal delivery, fetal and neonatal outcome were compared between two groups. RESULTS When compared to the controlgroup,the test group had much better effect on cervix mature and higher viginal de- livery. The time to labor starting and stage were much less in test group. There was no significant difference between two groups in postpartum hemorrhage, fetal and neonatal outcome. CONCLUSION Propess cervical maturing is safe. more effective and convenient than oxytocin with high success rate of labor induction.

关 键 词：地诺前列酮栓(前列腺素E2) 催产素 羊水过少 宫颈成熟 引产 

分 类 号：R969[医药卫生—药理学]