基于1,4:3,6-二缩水-D-果糖的噁唑烷衍生物的NMR研究  

NMR Study on Oxazolidne Derivatives of 1,4:3,6-Dianhydro-D-Fructose

作　　者：严琳[1] 刘丰五[2] 可钰[2] 刘宏民[2] 

机构地区：[1]河南大学药物研究所,河南开封475004 [2]郑州大学新药研究开发中心,河南郑州450052

出　　处：《河南大学学报（自然科学版）》2009年第4期360-364,共5页Journal of Henan University:Natural Science

基　　金：国家自然科学基金项目(20572103)

摘　　要：以1,4:3,6-二缩水-D-果糖为原料合成了4个新的噁唑烷衍生物,由于化合物中含有多个相同的结构单元,造成化学环境非常相似.采用1H NMR1、3C NMR、DEPT及二维谱1H-1H COSY、HSQC、HMBC和高分辨质谱(HRMS)对其1H1、3C NMR全谱给予了准确归属,并结合NOESY谱和相关化合物的X射线单晶衍射结果证实了化合物的立体结构.In this study, some new oxazolidine derivatives were prepared from 1, 4： 3, 6 dianhydro- D-fructose. Because of many same structural unils in these compounds, the chemical environment of these compounds was extremely similar. The structures of these oxazolidines were evaluated with 1D and 2D NMR spectroscopy （^1H NMR, ^13C NMR, DEPT-135, ^1H-^1H COSY, HSQC, HMBC） and HRMS spectra. ^1H NMR and ^13C NMR chemical shifts of these compounds were assigned. The stereochemistry of these compounds was established by the results obtained from X-ray crystal analysis of the relative compounds and NOESY spectroscopy.

关 键 词：核磁共振 归属 1 4 6-二缩水-D-果糖 噁唑烷衍生物 

分 类 号：O626.24[理学—有机化学]