海兰地嗪对正常及肺动脉高压大鼠肺动脉平滑肌细胞延迟整流钾电流作用的比较  

Comparison of effect of hernandezine on the delayed rectifierpotassium current of pulmonary artery smooth muscle cellof normal and pulmonary hypertensive rats1

作　　者：张庆利[1] 李智[1] 丛华[1] 李金鸣[1] 赫梅生[1] 

机构地区：[1]中国医科大学基础医学院药理学教研室

出　　处：《中国药理学与毒理学杂志》1998年第3期235-236,共2页Chinese Journal of Pharmacology and Toxicology

基　　金：中国卫生部八.五攻关资助

摘　　要：海兰地嗪对正常及肺动脉高压大鼠肺动脉平滑肌细胞延迟整流钾电流作用的比较１张庆利李智丛华李金鸣赫梅生（中国医科大学基础医学院药理学教研室，沈阳１１０００１）海兰地嗪（ｈｅｒｎａｎｄｅｚｉｎｅ，金丝马尾连碱甲）是从金丝马尾连根中提取分离的生物碱，据报道具...The delayed rectifier potassium currents of normal and chronic normobaric hypoxic pulmonary hypertensive rats and the effect of hernandezine on them were observed. The results showed that when cell membrane potential was held at -50 mV and command potential was larger than -50 mV, potential and timedependent delayed rectifier potassium currents were recorded, and the delayed rectifier potassium current of pulmonary hypertensive rats was smaller than that of normal rats. When command potential was +70 mV, the effect of hernandezine (0.1 mmol·L1) on the increased delayed rectifier potassium currents of pulmonary hypertensive rats (31±13%) was smaller than that of normal rats (59±13%).

关 键 词：肺动脉高压 肺动脉 平滑肌细胞 海兰地嗪 钾电流 

分 类 号：R543.2[医药卫生—心血管疾病] R972[医药卫生—内科学]