雌二醇对雌性大鼠血清载脂蛋白AI和B含量的影响  

Effect of Estradiol on Content of Apolipoprotein AI and B in Female Rat Serum

作　　者：马虹宇[1] 曹兴福[2] 王京花[2] 张丽敏[2] 

机构地区：[1]黑龙江省医院检验科,哈尔滨150036 [2]哈尔滨医科大学生理学教研室,哈尔滨150086

出　　处：《中国动脉硬化杂志》1998年第2期156-158,共3页Chinese Journal of Arteriosclerosis

基　　金：黑龙江省科委科学技术项目!G96C1916

摘　　要：为观察雌二醇对大鼠血清载脂蛋白AI和B含量的影响，用免疫比浊法和放射免疫分析法检测了性周期雌性大鼠、去卵巢大鼠和去卵巢注射雌二醇大鼠的血清雌二醇、载脂蛋白AI和B的水平。结果发现，在大鼠性周期中，血清雌二醇与载脂蛋白AI水平均呈周期性波动，两者的变化趋势一致。大鼠卵巢摘除后15天，血清雌二醇与载脂蛋白AI含量较未摘除卵巢大鼠显著降低（分别为0．82±0．32ng／L和0．51±0.11g／L），而注射雌二醇大鼠两者的含量又明显增加（分别为116．94±38．91ng／L和1．80±0．21g／L，P＜0.01）。但是，在性周期中、摘除卵巢和注射雌二醇大鼠血清中载脂蛋白B的含量无明显变化。提示，雌二醇可能调节雌性大鼠血中载脂蛋白AI的含量。The relationship between the level of estradiol (E2) and content of apolipoprotein AI and B in female rat serum during sexual cycle or after ovarectomy and injection of E2 was observed. The results indicate that there were cyclical changes of E2 and apolipoprotein AI content in female rat serum during sexual cycle, the tendency of changes of E2 and apolipoprotein AI was idencal, the highest values of them were obeserved at the period of proestrum. In ovariectomized rats the contents of E2, apolipoprotein AI in serum were significantly lower than those in each period of sexual cycle (P<0. 01 ). In ovariectomized and injected E2 group, the content of E2 and apolipoprotein AI were significantly higher than those in ovariectomized rats (P < 0. 01 ). The content of apolipoprotein B in serum remained unchanged either in sexuale cycle or in ovariectomized and injected E2group. This suggests that E2 may have a role to increase the content of apolipoprotein AI in serum.

关 键 词：雌二醇 血清 载脂蛋白AI 载脂蛋白B 调节作用 

分 类 号：R543.505[医药卫生—心血管疾病] R977.12[医药卫生—内科学]