脑络通胶囊抗鹌鹑动脉粥样硬化的实验研究  

Effects of Naoluotong Capsule on Experimental Atherosclerosis in Quails

作　　者：马杰[1] 周群[1] 杜佳林[1] 郭力辉[1] 张秀敏[1] 洪治平[1] 

机构地区：[1]辽宁省中医研究院病理生理室,沈阳110031

出　　处：《中国动脉硬化杂志》1998年第2期159-161,共3页Chinese Journal of Arteriosclerosis

基　　金：国家"八.五"科技攻关课题

摘　　要：为探讨脑络通胶囊抗鹌鹑动脉粥样硬化的机制，以食饵性高脂血症鹌鹑复制动脉粥样硬化模型，测量其血清中总胆固醇、甘油三脂，血浆中前列环素、血栓烷A2，脑组织中过氧化脂质、超氧化物歧化酶和谷胱甘肽过氧化物酶，并用评分法评估鹌鹑动粥样硬化的程度。结果发现，脑络通胶囊无降胆醇和甘油三酯的作用，但能显著升高超氧化物歧化酶的含量（P＜0．05），减轻动脉粥样硬化斑块的形成（P＜0．05）。提示，脑络通胶囊抑制动脉粥样硬化斑块形成的机理不是通过降血脂作用，而是通过抗氧化作用而奏效的。Aim: To study the mechanism of naoluotong on anti-atherosclerosis in quails.Methods: After the atherosclerosis (As) model in hyperlipemia quails were made,we measured the total cholesterol (TC ) and triglyceride (TG ) in serum, prostacyclin (PGI2 ) and thromboxane A2 (TXA2 ) in plasma, lipid peroxidation (LPO) and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)in brain tissuse. we estimated the grade of As by given points.Results: Naoluotong have no effects of reducing the amount of TC and TG, but increasing the amount of SOD (P<0. 05) and alleviating the formation of As plaque (P<0.05).Conclusion: The mechanism of naoluotong on inhibiting the formation of As plaque is not reducing hyperlipermia but antioxidation.

关 键 词：脑络通胶囊 动脉粥样硬化 鹌鹑 治疗 

分 类 号：R543.505[医药卫生—心血管疾病]