原婚与再婚家庭高血压遗传度分析  

ANALYSIS OF HERITABILITY OF HYPERTENSION IN THE ORIGINAL FAMILIES AND THE REMARRIED FAMILIES.

作　　者：张之玮[1,2] 赵晓芬[1,2] 孙乃诚 张连元[1,2] 周洪荣 董淑云[1,2] 韩向午[1,2] 

机构地区：[1]华北煤炭医学院 [2]唐山唐家庄矿医院

出　　处：《现代预防医学》1998年第2期167-169,共3页Modern Preventive Medicine

基　　金：国家自然科学基金

摘　　要：以唐山原婚家庭７４例原发性高血压患者为先证者进行了家系调查，并对４８４户再婚家庭进行了高血压现患调查。用Ｆａｌｃｏｎｅｒ法、组内相关法和中亲——子代回归法估算了原婚家庭高血压遗传度。除组内相关法舒张压遗传度为５０．４０％外，余均大于６２％。用组内相关法估算再婚家庭高血压遗传度，除半同胞收缩压遗传度为４８．４４％外，余均大于６４％。n Tangshan,we made family investigation for 74 cases of essential hypertension in the original families and made generally survey of hypertension for 484 remarried families.We got the heritability(h2) of essential hypertension h2=764±21% by using the data of the second degree relatives for original families(method of falconer).Adopting the method of correlation inside of groups,we analyzed the heritability of hypertension for remarried families,h2>64% except that h2 of SBP was 48% for half siblings.The results show that the effect of genetic factors is relatively more important than the environmental factors in the pathogeny of hypertension.

关 键 词：再婚家庭 高血压 遗传度 遗传因素 流行病学 

分 类 号：R544.1[医药卫生—心血管疾病]