太湖区域环境中基于PBPK模型的DDTs和HCHs混合健康风险  

PBPK model-based DDTs-HCHs mixed health risk in Lake Taihu region

作　　者：赵肖[1,2] 廖岩[1] 李适宇[2] 

机构地区：[1]国家环境保护部华南环境科学研究所,广州510655 [2]中山大学环境科学与工程学院,广州510275

出　　处：《生态学杂志》2009年第8期1624-1629,共6页Chinese Journal of Ecology

基　　金：中央级公益性科研院所基本科研业务专项资助项目(206030201)

摘　　要：针对太湖区域环境中DDTs和HCHs混合暴露的健康危害,基于对居民DDTs及HCHs不同途径暴露量的分析,通过建立DDTs及HCHs的PBPK模型,分析其在人体内的累积分布过程,并应用内效应综合危害指数评价其混合暴露的健康风险。结果表明,居民健康风险度分别为0.147～2.499(男性)和0.138～2.223(女性),超过可接受风险的概率分别为24.6%(男性)和16.5%(女性)。相较于传统的混合健康风险评价方法(HI法),基于PBPK模型的内效应综合危害指数法(HItissue-dose)更能反映混合健康风险的发展趋势。Based on the investigation of residents DDTs-HCHs mixed exposure via different ways in Taihu Lake region, a physiologically based pharmacokinetic （PBPK） model was built to analyze the distribution and accumulation processes of the pesticides in human tissues, and a tissue dose hazard index was used to assess the health risk of the mixed exposure. For the male and female residents, their health risk index was 0. 147-2. 499 and 0. 138-2. 223, and the probability of exceeding the acceptable risk was 24. 6% and 16. 5%, respectively. Comparing with the tra- ditional mixed health risk assessment method, i. e. , HI method, the PBPK-based tissue dose hazard index （HItissue-dose） could better reflect the development trend of mixed health risk.

关 键 词：太湖 滴滴涕 六六六 药代动力学模型 健康风险 

分 类 号：X524[环境科学与工程—环境工程]