大鼠长期服用左旋多巴后主动脉平滑肌中AT_1受体的变化  

A LONG-TERM FEEDING OF LEVODOPA ON RATS AND THE CHANGES OF AT1 RECEPTOR IN THEIR AORTIC SMOOTH MUSCLES

作　　者：张梅[1] 张红[1] 赵荣瑞[1] 

机构地区：[1]山西医科大学

出　　处：《山西医药杂志》1998年第4期306-308,共3页Shanxi Medical Journal

摘　　要：为研究多巴胺对肾素—血管紧张素系统的调节作用，本研究利用离体血管收缩实验观察了服用左旋多巴后大鼠主动脉平滑肌中血管紧张素ＡＴ１受体的变化情况。结果表明在服用左旋多巴１周、２周、４周后主动脉对血管紧张素Ⅱ（ＡｎｇⅡ）的反应性下降，最大收缩反应分别为４７２．７９ｍｇ±７４．５９ｍｇ、４９２．３９ｍｇ±６９．６１ｍｇ和３０２．２６ｍｇ±６１．６０ｍｇ，较对照组（６０３．８３ｍｇ±５６．２１ｍｇ）明显为低。用药组主动脉对ＡｎｇⅡ之累积浓度收缩曲线比对照组显著下移，且以４周组最为显著，但ｐＤ２值在各组间无明显差异（Ｐ＞０．０５），表明血管本身的反应性未发生显著改变。上述结果表明多巴胺能引起主动脉中ＡＴ１受体水平下调，提示多巴胺在治疗高血压中除作用于多巴胺系统外。Many reports demonstrated that reninangiotensinsystem and dopamine system have opposite effects on kidney.Both of them are important components in cardiovascular system,thus,in this research we employed isolated blood vessel ring assay to study the changes of angiotensin Ⅱ (Ang Ⅱ) receptor AT1 subtype(AT1) in rat aortic smooth muscles after oral levodopa (LDOPA).The results indicated that after oral LDOPA,the reaction of rat aorta to AngⅡ decreased obviously.During the first two weeks of infusion,the E_max values were 472.79 mg±74.59 mg and 492.39 mg±69.61 mg respectively with no statistical significance (P>0.05 vs control).Whereas,after 4 weeks of infusion,the E_max significantly decreased to 302.26 mg±61.60 mg vs 603.83 mg±56.21 mg in control (P<005).These results suggest that dopamine can regulate aortic AT1 receptor in a heterologous manner.

关 键 词：左旋多巴 AT1受体 高血压 药物疗法 大鼠 

分 类 号：R544.105[医药卫生—心血管疾病] R965[医药卫生—内科学]