降钙素基因相关肽在诱发实验犬过敏性支气管哮喘中的变化  

The change of calcitonin generelated peptide in experimental canine allergic bronchial asthma

作　　者：蒋超英[1] 胡红[1] 刘又宁[1] 朱宝华[1] 朴哲龙[1] 郝峰英[1] 

机构地区：[1]解放军总医院呼吸科

出　　处：《军医进修学院学报》1998年第3期201-203,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的：观察降钙素基因相关肽（ＣＧＲＰ）在过敏性支气管哮喘发病机制中的作用。方法：用猪蛔虫蛋白激发实验犬过敏性支气管哮喘，ＲＩＡ法检测血浆及支气管肺泡灌洗液（ＢＡＬＦ）中ＣＧＲＰ。结果：血浆中ＣＧＲＰ在激发哮喘后１ｈ显著下降，ＢＡＬＦ中ＣＧＲＰ在激发后１ｈ和２ｈ显著低于激发前和激发后即刻的水平。这种变化趋势可能与肺组织中ＣＧＲＰ受体与ＣＧＲＰ结合率的升高有关。Objective:To observe the effect of CGRP in the pathogenefic mechanism of bronchial asthma.Methods:The experimental canine allergic bronchial asthma was induced with Ascaris ovum extract antigen. The CGRP in dog plasma and BALF was measured by radioimmunoassy. Results:The plasma CGRP decreased significantly 1 hour after asthma was evoked, and the CGRP in BALF also significantly decreased at 1 and 2 hours compared with that before evocation or immediately after evocation. These tendencies of change were probably related to the increase of the combination rate of CGRP receptor.Conclusion:The observation suggests that the neurogenic inflammatory response may be involved in the pathogenesis of bronchial asthma.

关 键 词：哮喘 CGRP 发病机制 

分 类 号：R562.250.2[医药卫生—呼吸系统]