羟基红花黄色素A在血瘀和正常大鼠体内药动学研究  

Study on Pharmacokinetics of Hydrosafflor Yellow A in Blood Stasis and Normal Rats

作　　者：乔逸[1] 杨志福[1] 奚苗苗[1] 田云[1] 贾艳艳[1] 杨静[1] 陈敏纯[1] 文爱东[1] 

机构地区：[1]第四军医大学西京医院药剂科,西安710032

出　　处：《中国药师》2009年第8期995-997,共3页China Pharmacist

基　　金：国家自然科学基金资助项目(30672662)

摘　　要：目的:研究羟基红花黄色素A(HSYA)在血瘀和正常大鼠体内的药物动力学特征。方法:采用HPLC法测定血瘀与正常大鼠血浆中HSYA的血药浓度,应用DAS 2.0求得药动学参数。结果:血瘀大鼠和正常大鼠C_(max)分别为(8.36±1.09)和(4.61±0.19)mg·L^(-1);t_(max)分别为(1.19±0.55)和(0.75±0.00)h;AUC_(0-6)分别为(23.16±2.88)和(8.68±0.93)mg·L^(-1)·h;t_(1/2β)分别为(1.00±0.30)和(0.98±0.15)h。结论:HSYA在急性血瘀大鼠体内吸收和代谢均明显慢于正常大鼠体内,说明血瘀证可以改变药物的代谢过程。Objective ： To study the pharmacokinetie character of hydrosafflor yellow A （ HSYA ） in blood stasis and normal rats. Methods： The concentrations of HSYA in blood stasis rats and normal rats plasma were analyzed by HPLC. The pharmaeokinetie parameters were calculated by the software DAS 2.0. Result： The main pharmaeokinetic parameters were as follows in blood stasis rats and normal rats： Cmax were（8.36±1.09）and4.61±0.19）mg·L^-1, respectively, tmax were（1.19±0.55）and（0. 75±0. 00）h, respectively. AUC0-6 were （23.16 ±2.88） and （8.68 ±0. 93） mg·L^-1 · h, respectively, t1/2βwere（ 1.00 ±0.30）and（0.98 ±0.15） h, respectively. Conclusion ： The absorption and metabolism of safflor yellow is evidently later in acute rat model of blood stasis syndrome than normal rats, which shows that the pharmaeokinetieal character of safflor yellow can be changed by syndrome.

关 键 词：羟基红花黄色素A 高效液相色谱法 血瘀大鼠 药物动力学 

分 类 号：R969.1[医药卫生—药理学]