ACEI与ARB联合治疗糖尿病肾病疗效观察  

Study of Therapeutic Efficacy of Combination ACEI and ARB on Diabetic Nephropathy

作　　者：张建荣 

机构地区：[1]绍兴市第七人民医院,浙江绍兴312000

出　　处：《中国药师》2009年第8期1106-1107,共2页China Pharmacist

摘　　要：目的:研究血管紧张素转换酶抑制药(ACEI)和血管紧张素受体拮抗药(ARB)对2型糖尿病肾病患者肾功能的保护作用。方法:选择有肾功能损害的糖尿病病人90例,在常规糖尿病治疗的同时,随机分成3组,分别给予ACEI、ARB、ACEI合并ARB治疗,观察治疗前后24h尿蛋白的变化。结果:3组患者治疗后尿蛋白排泄均减少,差别有统计学意义(P<0.05),而联合治疗组与其他两组相比,差别有统计学意义(P<0.05)。结论:ACEI和ARB联用能更好地起到肾脏保护作用。Objective： To investigate the protective effect of angiotensin-converting enzyme inhibitor （ ACEI） and angiotensin receptor antagonist（ ARB ） on renal function of patients with type 2 diabetic nephropathy. Method： Ninety patients with type 2 diabetic nephropathy and damages of renal function were observed. The patients all accepted routine diabetic therapy and were randomly divided into three groups, ACEI group, ARB group and combination group with ACEI and ARB. The urine protein of 24 hours were measured before and after therapy. Result ： The excretive amounts of urine protein significantly decreased in all groups （ P 〈 0.05 ）. The excretive levels of urine protein in combination group significantly decreased than that of ACEI group and ARB group （ P 〈 0.05 ）. Conclusions： Combination with ACEI and ARB in clinics might have more protective effect on renal in patients with diabetic nephropathy.

关 键 词：血管紧张素转换酶抑制药 血管紧张素受体拮抗药 糖尿病肾病 联合治疗 

分 类 号：R927.4[医药卫生—药学]