休克大鼠小肠微循环灌流量和血清TNF的变化及多巴胺的作用  

Changes in Microcirculatory Perfusion of Small Intestine and Concentration of Serum TNF in Shock Rats and the Effects of Dopamine on them

作　　者：安乐彬 王雪雯[2] 张明[3] 张国平[3] 金惠铭[3] 

机构地区：[1]上海职工医学院病理生理学教研室,上海200237 [2]新疆石河子医学院病理生理学教研室 [3]上海医科大学病理生理学教研室

出　　处：《中国微循环》1998年第2期79-81,共3页Journal of Chinese Microcirculation

摘　　要：在39只失血性休克大鼠中，用激光多普勒微循环血流计及ELISA法测定静脉注射多巴胺前后小肠微循环增流量及血清TNF浓度的变化。结果发现随休克发展，小肠微循环血液灌流量进行性减少，TNF浓度升高。多巴胺（40μg／100gB．W．）治疗可增加小肠微循环血液油流量和降低血清TNF浓度。两者间呈显著性相关（r＝0．897，P＜0．01）。作者认为，多巴胺通过增加小肠微循环血液灌流量，改善肠壁屏障功能，减少内毒素入血，从而降低血清TNF浓度，保护了脏器功能和减轻细胞损伤。Using Lasser Doppler Flowmeter and ELISA the perfusion of small intestine and the concentration of serum TNF were measured before and after venous injection of Dopamine in 39 hemorrhagic shock rats. The results show that with the development of shock there was a progressive decrease in perfusion ofsmall intestine and an increase in collcentration of serum TNF After venous injection of Dopamine (40μg/100gB. W. )the perfusion of small intestine increased and the concentration of serum TNF decreased. There was a significant correlation between them(r=0. 897,P<0.01 ). Authors suggested that the barrier function of small intestine may be improved by the increase in perfusion of small intestine after venous injection of Dopamine. Then the endotoxin entering the blood from intestine was reduced and the concentration of serum TNF decreased. These changes may protect organs and cells from the damage during shock.

关 键 词：休克 小肠 肿瘤坏死因子 灌流量 多巴胺 

分 类 号：R605.971[医药卫生—急诊医学] R656.7[医药卫生—外科学]