系统性红斑狼疮患者血清IL-18、sVCAM-1和VEGF水平及其意义  

Determination and Clinical Significance of Serum Levels of IL-18,sVCAM-1 and VEGF in Patients with SLE

作　　者：黄镜招 刘瑞玉[2] 钟伟强[2] 巫远忠[2] 张丽科[2] 黄铁峰[2] 

机构地区：[1]广东省惠州市中医医院检验科,惠州516001 [2]广东省惠州市中心人民医院,惠州516001

出　　处：《热带医学杂志》2009年第7期782-784,共3页Journal of Tropical Medicine

摘　　要：目的探讨白细胞介素18(IL-18)、可溶性血管黏附分子-1(sVCAM-1)和血管内皮生长因子(VEGF)水平变化与系统性红斑狼疮(SLE)发病机制的关系。方法采用酶联免疫ELISA法检测SLE患者35例,正常对照组25例血清IL-18、sVCAM-1和VEGF的水平。结果SLE组IL-18(521.23±134.29)pg/mL、sVCAM-1(1179.25±225.57)ng/mL、VEGF(198.85±41.96)pg/mL,较正常对照组IL-18(256.39±59.52)pg/mL、sVCAM-1(538.16±91.21)ng/mL、VEGF(125.62±32.15)pg/mL明显升高,差异有统计学意义(P均<0.01)。活动期SLE患者IL-18(687.44±158.60)pg/mL、sVCAM-1(1478.14±322.72)ng/mL、VEGF(236.25±48.62)pg/mL与非活动期组SLEIL-18(355.02±109.98)pg/mL、sVCAM-1(881.37±128.30)ng/mL、VEGF(160.47±35.79)pg/ml之间比较,差异有统计学意义(P均﹤0.01)。结论SLE患者IL-18、sVCAM-1和VEGF水平增高,且与疾病的活动性相关。Objective To study the serum levels of interleukin 18 （IL- 18 ）, soluble vascular adhesion molecule （sVCAM-1） and Vascular endothelial growth factor （VEGF）in patients with systemic lupus erythematosus （SLE） and their clinical significance. Methods Enzyme linked immunosorbent assay（ELISA） was used to detect IL- 18, sVCAM-I and VEGF in serums of 35 patients with SLE and 25 normal controls. Results The serum levels of IL-18, sVCAM-1 and VEGF in patients with SLE [ （521.23 ±134.29）pg/mL, （ 1179.75±225.57）ng/mL, （198.85 ± 41.96）pg/mL] were significantly higher than those in controls[（256.39±59.52）pg/mL, （538.16±91.21）ng/mL, （125.62±32.15）pg/mL] （P〈0.01）. And the levels of IL-18, sVCAM-1 and VEGF [ （687.44±158.60）pg/mL, （1478.14±322.72）ng/mL, （236.25±48.62）pg/mL] in active systemic lupus erythematosus patients were higher than those in non-active systemic lupus erythematosus patients [（355.02 ±109.98）pg/mL, （881.37 ±128.30）ng/mL, （160.47±35.79）pg/mL] （P〈0.01）. Conclusion The serum levels of IL-18, sVCAM-1 and VEGF in SLE were higher in the SLE patients than those in control group, and were related to the activities of SLE.

关 键 词：红斑狼疮 系统性 白细胞介素18 可溶性血管细胞黏附分子-1 血管内皮生长因子 

分 类 号：R593.241[医药卫生—内科学]