佛山地区淋球菌流行株对抗生素敏感性测定  

Detection of the Antibiotics Susceptibe Epidemic Strains of Neisseria gonorrhoeae in Foshan City

作　　者：李燕娃 潘洪亮 吴兴中[2] 

机构地区：[1]广东省佛山市皮肤病防治所,佛山528000 [2]广东省皮肤性病防治中心,广州510500

出　　处：《热带医学杂志》2009年第7期796-798,共3页Journal of Tropical Medicine

摘　　要：目的了解佛山地区2007年分离的淋球菌流行株对青霉素、四环素、大观霉素、头孢曲松和环丙沙星的耐药性及产β-内酰胺酶淋球菌(PPNG)和四环素高度耐药淋球菌(TRNG)的流行状况。方法采用琼脂稀释法测定最小抑菌浓度(MIC),纸片酸度法检测β-内酰胺酶。结果98株淋球菌检出PPNG34株(34.7%),TRNG63株(64.3%)。青霉素、环丙沙星和四环素的耐药率分别为96.9%、96.9%和94.9%,未发现大观霉素及头孢曲松耐药株。青霉素﹑四环素和环丙沙星的MIC50及MIC90均已超过耐药标准,尤以青霉素为甚,其MIC50及MIC90均超过耐药标准的8倍和32倍。结论大观霉素及头孢曲松是治疗淋病的首选药物。Objective To investigate the antibiotics susceptibility of Neisseria gonorrhoeae isolated in Foshan city in 2007. Methods Agar dilution method was used to determine the minimum inhibitory concentrations （MICs） of the isolates to penicillin G, tetracycline, ciprofloxacin, ceftriaxone and spectinomycin. Penicillinase produced by N. gonorrhoeae （PPNG） was analysed by the paper acidometric method. Results 98 N. gonorrhoeae isolates were identified, in which 34.7% were PPNG and 64.3% were TRNG. The percentage of drug resistance to penicillin, ciprofloxacin and tetracycline was 96.9%, 96.9% and 94.9%, respectively. Ceftriaxone and spectinomycin resistant strains were not found. The values of MIC50 and MIC50 of penicillin, tetracycline and ciprofloxacin for these isolates were significantly greater than the standards. Especially, the values of MIC50 and MIC50 of penicillin was 8 and 32 times respectively higher than the standard. Conclusion Ceftriaxone and spectiomycin should be used as the first-line agents in treating gonorrhoea.

关 键 词：淋球菌 抗菌药物 耐药性 

分 类 号：R378.1[医药卫生—病原生物学]