卡维地洛加小剂量螺内酯逆转高血压左室肥厚  

Carvedilo with low dose of spironolactone in reversal of hypertensive left ventricular hypertrophy

作　　者：郑新玲[1] 樊静[1] 金烈[1] 潘佚斌[1] 

机构地区：[1]金华市中心医院心内科,浙江金华321000

出　　处：《中国新药与临床杂志》2009年第7期550-552,共3页Chinese Journal of New Drugs and Clinical Remedies

基　　金：浙江省金华市自然科学基金资助项目(2004-2-313)

摘　　要：目的评价卡维地洛加小剂量螺内酯逆转高血压左室肥厚作用。方法高血压左室肥厚病人60例分为2组(各30例),治疗组给予卡维地洛10～25mg,qd,加螺内酯20～40mg,qd;对照组给予美托洛尔12.5～25mg,bid,加氢氯噻嗪12.5mg,qd。疗程6～24mo。治疗前后采用超声心动图检查,比较2组左心室结构及功能变化,并随访6、12和24mo。结果治疗后2组血压均显著下降(P<0.01),治疗组左室后壁厚度、室间隔厚度和左室重量指数均较治疗前有显著降低(P<0.01),对照组无明显变化(P>0.05),2组间有显著差异(P<0.01)。结论卡维地洛加小剂量螺内酯有明显逆转高血压左室肥厚作用。AIM To evaluate the effects of carvedilol with low dose of spironolactone in reversing hypertensive left ventricular hypertrophy. METHODS Sixty patients with hypertensive left ventricular hypertrophy were divided into two groups randomly with 30 patients in each. The treated group was given carvedilol 10 - 25 mg qd combined with spironolactone 20 - 40 mg qd. The control group was given metoprolol 12.5 - 25 mg bid together with hydrochlorothiazide 12.5 mg qd. All patients in the two groups were under taken ultrasonic cardiogram and then followed by comparisons of the shown left ventricular structural and functional changes before and after the treatment, with follow-up to 6, 12, and 24 mo. RESULTS In addition to the prominent reduction of hypertension in both groups （P 〈 0.01 ） , the reversal of left ventricular hypertrophy including all the related parameters was significant in patients of the treated group comparing with the control group （P 〈 0.01 ）; but no significant change occurred in the control group （P 〉 0.05） . There were significant differences between the two groups （P 〈 0.01 ） . CONCLUSION Carvedilol with low dose of spironolactone provides high efficacy for the reversal of hypertensive left ventricular hypertrophy.

关 键 词：卡维地洛 螺内酯 肥大 左心室 高血压 

分 类 号：R972.4[医药卫生—药品] R544.1[医药卫生—药学]