一种新的创面覆盖物——丝素膜  

A new burn wound covering-fibroin membrane

作　　者：黄伯高[1] 朱德安[1] 吴征宇 严攸鸣 廖镇江 田保中[2] 贾生贤[1] 史济湘[1] 

机构地区：[1]上海第二医科大学附属瑞金医院烧伤科,200025 [2]苏州丝绸工学院 [3]苏州第三人民医院

出　　处：《中华整形烧伤外科杂志》1998年第4期270-274,323,共5页

摘　　要：目的检测丝素膜的物理及生物学性能,并且评价其临床效果。方法①实验室检测:应用各种先进仪器分别测定丝素膜及断层猪皮的含水率、断裂强度、柔韧性、透水性、创面粘合力等物理及生物学特性指标。②临床观察:于同一个体选深度相似的两块创面分别应用丝素膜及1％SD-Ag 冷霜,然后对比观察两块创面的变化。结果该膜具有与断层猪皮相近的物理及生物学特性。无毒,无刺激性及抗原性。具有一定的透水性,并能与创面产生良好的初期粘合。由于其完全透明,故可直接观察到膜下创面的变化,有助于临床治疗及实验研究。临床观察结果该膜具有良好的保护创面作用,其应用可明显减轻创面疼痛,创面愈合时间较对照组提前3～5天。结论该膜是较为理想的创面覆盖物,值得推广。Objective This study was aimed at determining the physical and biological properties of fibroin membrane and evaluating its clinical effects.Methods ①The physical and biological proper- ties of fibroin membrane and partial thickness porcine skin were determined with various instruments. The determinations included water ratio,tensile strength,flexibility,water permeability,adhesive force and so on.②Clinical observation:Two wounds with same depth in the same patient were selected.One was covered by fibroin membrane.The other one was treated with 1% SD-Ag cream.The changes in these wounds were observed and compared.Results This membrane had nearly same physical and bio- logical properties compared with partial thickness porcine skin.It had no toxicity,irritation,and anti- genicity.It possessed certain amount of water permeability and could adhere to the wound.Because of its good transparency,any change in underlying wound could be directly observed.It was helpful not only in local therapy but also in study of wound healing.Clinical observations showed that this membrane had good protecting effect to wound.Its application could obviously relieve pain of wound and the healing time was 3-5 days ahead than that of the control wound.Conclusion This membrane was an ideal wound covering and was worth being popularized.

关 键 词：烧伤 创面覆盖物 丝素膜 

分 类 号：R644.05[医药卫生—外科学]