生长激素在成人大面积深度烧伤的应用  

The effect of growth hormone on wound healing rate in adult burns

作　　者：孙永华[1] 周业平[1] 蒋朱明[2] 苏虹[1] 闫汝蕴[1] 陈忠[1] 崔世日[1] 

机构地区：[1]北京积水潭医院烧伤科,100035 [2]北京协和医院外科

出　　处：《中华整形烧伤外科杂志》1998年第4期277-280,共4页

摘　　要：目的探讨生长激素对成人烧伤创面愈合、感染的发病率,住院日以及预后的作用。方法选择1996年2月至1997年6月间,16例烧伤面积大于50％,Ⅲ度面积大于40％的重度烧伤患者,并随机分为重组人生长激素组(rHGH group)和对照组(control group),伤后当天及20天取外周血进行氨基酸谱分析,记录植皮区和供皮区创面愈合时间以及住院时间,计算伤后第30天全身创面愈合率。结果rHGH 组精神状态和食欲较好,血浆氨基酸谱分析,术后抗生素应用剂量及时间,植皮区和供皮区愈合时间,住院日等 rHGH 组均优于对照组。结论伤后早期开始使用 rHGH 有助于改善全身状况,促进创面愈合,减少并发症。Objective To determine the wound healing effect of rHGH in adult burn patients. Methods 16 patients with burn wounds covering over 60% of total body surface(TBSA)were enrolled in this pacebo controlled prospective study.They were comparable in nutrient intake,TBSA,and full thickness burn area.rHGH group patients werer given rHGH subcutaneously in the dose of 0.3u.Kg^(-1) at 8 am each morning for 10 days beginning from POD 1.The control group patients were given normal saline as placebo.All the patients received escar excision within 4 days postburn,and the excision wounds were covered with autologous skin pulp grafting.Serum amino acid profile was analyzed at day 1 and day 20 post burn.Healing time of burn wound area and donor site was recorded.Wound healing rate was assessed at day 30 after day.Results ①The healing time of autologous skin pulp grafting and donor site,and the length of hospital stay were significantly shorter in GH group patients than control group.②The amino acid profile showed no difference between two groups at day 1 and was significantly better in GH group at day 20.Conclusion rHGH could enhance the wound healing rate,improve amino acid profile,and reduce the length of hospital stay of severe burn patients.

关 键 词：烧伤 生长激素 皮肤移植 

分 类 号：R644.05[医药卫生—外科学] R622.1[医药卫生—临床医学]