2型糖尿病患者窦性心律震荡与24h尿蛋白关系的研究  

Study on the Relationship between Heart Rate Turbulence and 24-Hour Urine Protein in Type 2 Diabetes Mellitus

作　　者：王开成[1] 孙金明[1] 俞红丽[1] 倪国金 任益红 楼祥云 

机构地区：[1]杭州市萧山区第三人民医院内二科,311251

出　　处：《心电学杂志》2009年第4期242-243,245,共3页Journal of Electrocardiology(China)

摘　　要：目的探讨2型糖尿病伴室性期前收缩患者窦性心律震荡的变化及与24h尿蛋白的关系。方法57例伴室性期前收缩的2型糖尿病患者被分为正常白蛋白尿组（n=18）、微量白蛋白尿组（n=19）、临床白蛋白尿（n=20），记录24h动态心电图，计算及比较各组震荡初始（TO）和震荡斜率（TS）。结果临床白蛋白尿组和微量白蛋白尿组TO[分别为（O08±0．67）％、（007±0．72）％]高于正常白蛋白尿组（-179±0．41）％，而TS[分别为（5．09±128）ms／R—R、（5．01±1．04）ms／R—R）低于正常白蛋白尿组（839±1．05）ms／R—R，差异均有非常显著性意义（P〈0.01）。结论2型糖尿病患者TO明显升高，TS明显下降，其变化程度与24h尿蛋白量密切相关。Objective To investigate the relationship between heart rate turbulence and 24-hour urine protein in type 2 diabetes mellitus（DM）. Methods 57 type 2 DM patients with ventricular premature beat were divided into normoalbuminutia group （group A, n=18）, microalbuminuria group （group B, n=19） , albuminuria group （group C, n=20）. Turbulence onset （TO） and turbulence slope （TS） were calculated based on 24-hour ambulatory ECG and compared among different groups. Results TO was significantly higher in group C （0.08 ± 0.67）% and group B （0.07 ± 0.72）%than in group A（ -1.79 ± 0.41 ）%（ all P 〈 0.01 ）. TS were significantly lower in group C（ 5.09 ± 1.28 ） ms / R-R and group B（ 5.01 ± 1.04 ）ms / R-R than in group A（ 8.39 ± 1.05 ）ms / R-R （ all P 〈 0.01 ）. Conclusion TO increases and TS decreases obviously and their changes are closely related to 24-hour urine protein measurements in type 2 DM patients.

关 键 词：2型糖尿病 窦性心律震荡 24h尿蛋白 

分 类 号：R540.41[医药卫生—心血管疾病] R587.1[医药卫生—内科学]