外翻肠囊法评价及比较5种药物大鼠肠透膜能力  

Evaluating and Comparing the Intestine Permeability of 5 Kinds of Drugs by Everted Intestinal Sac Method

作　　者：刘晓颖[1] 苏湲淇[1] 甘晓玲[1] 龚萍[1] 段春燕[1] 张亚红[1] 

机构地区：[1]重庆医药高等专科学校,重庆市400030

出　　处：《中国药房》2009年第22期1704-1706,共3页China Pharmacy

基　　金：重庆市教委科学技术研究项目(KJ072202)

摘　　要：目的:考察外翻肠囊法在评价及比较多种药物肠透膜能力方面的可行性与实用性。方法:按外翻肠囊法制备大鼠肠吸收离体模型,测定西酞普兰、布洛芬、酮洛芬、氯霉素、盐酸地尔硫5种药物的累积吸收率,并与该5种药物经脂质体毛细管电泳(LCE)法所测得的脂水分配系数(logP)排序结果比较。结果:5种药物在大鼠小肠壁均有不同程度的吸收,累积吸收率由高至低依次为西酞普兰>盐酸地尔硫>布洛芬>酮洛芬>氯霉素,与LCE法测定结果一致。结论:外翻肠囊法可评价及比较多种药物的肠透膜能力。OBJECTIVE： To investigate the feasibility and practicability of evaluating and comparing the drug permeability by everted intestinal sac method. METHODS： The ex vivo intestinal absorption rat model was established by everted intestinal sac method, and the accumulative absorption rate of five drugs including citalopram, ibuprofen, ketoprofen, chloramphenicol, diltiazem hydrochloride were calculated. The rate were compared with the order of lipid - water distribution coefficient （logP） of the 5 drugs determined by liposome capillary electrophoresis （LCE） method. RESULTS： All the five drugs presented different degree of permeability in intestine, and the 5 drugs ranked in descending order in terms of accumulative absorption ratios were as follows： citalopram〉 diltiazem hydrochloride〉 ibuprofen〉 ketoprofen〉 chlormaphenicol, and this result was in line with the result determined by LCE. CONCLUSION： Drug permeability of multi - kind of drugs in intestine can be evaluated and compared by everted intestinal sac method.

关 键 词：外翻肠囊法 大鼠 药物 累积吸收率 肠透膜能力 

分 类 号：R965[医药卫生—药理学]