双半乳糖基二酰甘油酯作为一种自组装载体材料的初步研究  

Exploratory study on digalactosydiacyl-glycerol as a self-assembly carrier material

作　　者：李新刚[1] 赵庆春[2] 高春凤[1] 邢传峰[1] 赵秀丽[1] 陈大为[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]沈阳军区总医院药剂科,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2009年第8期591-595,603,共6页Journal of Shenyang Pharmaceutical University

摘　　要：目的对从燕麦麸皮中分离得到的非离子型表面活性剂双半乳糖基二酰甘油酯(digalactosyl-diacylglycerol,DGDG)进行初步研究。方法采用丙酮提取,硅胶柱分离DGDG,NMR法鉴定结构,并对其亲水亲油平衡值(hydrophile-lipophile balance,HLB)、临界胶束浓度(critical micelle concen-tration,CMC)和自组装性能进行研究。结果分离得到了DGDG,其HLB值为8.15、CMC为2 mg.L-1,并可自组装成为双分子层。结论DGDG可作为一种具有自组装性能的载体材料。Objective To study on a new type nonionic wetting agent-digalactosydiacylglycerol （DGDG） which was isolated from oat bran. Methods Oat oil was extracted by acetone from oat bran, and DGDG was isolated by silica gel column from oat oil. Chemical methods and NMR data were used to identify the structure Of DGDG. Its hydrophile-lipophile balance value（ HLB）, critical micelle concentration（CMC） and selfassembly performance were researched through preparing vesicle which has inner aqueous phase. Results DGDG was obtained successfully and its NMR data were consistent with literature. Its HLB and CMC concentration were 8. 15 and 2. 00 mg.L^-1, respectively. The vesicle which has inner aqueous phase can be formed by its self. Conclusions DGDG can be used as a kind of carrier material which has self-assembly performance.

关 键 词：表面活性剂 双半乳糖基二酰甘油脂 自组装 

分 类 号：R94[医药卫生—药剂学]