二苯乙烯苷对D-半乳糖衰老模型小鼠衰老指征的影响  

The anti-aging effects of stilbeng glucoside on aging mice induced by D-galactose

作　　者：宋士军[1] 李欣[2] 刘纪钊[2] 李芳芳[1] 

机构地区：[1]河北医科大学基础医学院,石家庄050017 [2]河北省邯郸市第一医院外科

出　　处：《陕西医学杂志》2009年第8期951-953,共3页Shaanxi Medical Journal

摘　　要：目的:探讨二苯乙烯苷对D-半乳糖所致亚急性衰老的影响。方法:将174只小鼠随机分为三组,即对照组、衰老模型组和二苯乙烯苷组,分别给予生理盐水、D-半乳糖和D-半乳糖+二苯乙烯苷,六周后部分小鼠测定游泳时间,耐缺氧、耐寒和耐高温能力。另一部分小鼠测定不同组织脂褐素(LPF)、Na+/K+-ATP酶、超氧化物歧化酶(SOD)和丙二醛(MDA)含量。测定二苯乙烯苷对人红细胞膜的MDA的生成量的影响。结果:二苯乙烯苷明显延长游泳时间、耐缺氧和耐高温能力,二苯乙烯苷可降低小鼠脑组织LPF含量,升高心肌Na+/K+-ATP酶和肝脏SOD活性。二苯乙烯苷可减少邻苯三酚所致的人红细胞膜MDA的生成。结论:二苯乙烯苷具有抗衰老作用,其机制是通过多种途径而实现的。Objective： To investigate the effects of stilbene glucoside（SG） on sub-acute aging mice induced by D-galactose. Methods ： One handred and seventy four mice were divided randomly into three groups ： control group, model group and SG group;Mice were given normal saline, D-galactose and D-galactos ＋SG respectively. Swimming time, hypoxia tolerance ability , anti-cold ability and anti-hot ability of parts of mice were measured after sixth week. Meanwhile, the quantities of lipofusein（LPF）, malonaldehydic acid （MDA） , the activeties of Na^＋/K^＋ -ATPase and superoxide dismutase （SOD） were measured in parts of another mice. The quantity of MDA on membrane of human erythrocyte was measured in treated SG. Results： SG prolonged swimming time, enhanced bypoxia tolerance ability and anti-hot ability,SG decreased the quantity of LPF in brain, enhanced the activity of Na^＋/K^＋-ATPase in heart and SOD in liver. It also decreased the quantity of MDA induced by pyrogallol on membrane of erythrocyte. Conclusion： SG has the function of antiaging.

关 键 词：衰老 二苯乙酸类 半乳糖 动物 实验 小鼠 

分 类 号：R285.5[医药卫生—中药学] R286.0[医药卫生—中医学]