益肝冲剂质量标准研究  

Quality standard study for Yigan powder

作　　者：杜憬生[1] 吴晓薇[1] 吴寿海[2] 

机构地区：[1]广东省中医院,广州101200 [2]广州中医药大学,广州104050

出　　处：《海峡药学》2009年第7期83-85,共3页Strait Pharmaceutical Journal

摘　　要：目的建立益肝冲剂的质量标准。方法采用TLC法对制剂中延胡索和厚朴进行定性鉴别;采用HPLC法测定丹参酮ⅡA的含量。选择C18柱,以甲醇-水(75∶25)为流动相,流速为1.2mL.min-1,检测波长为270nm。结果在TLC图谱中可检出延胡索和厚朴的特征斑点。丹参酮ⅡA在7.92μg.mL-1～79.2μg.mL-1的浓度范围内线性关系良好,r=0.9995,平均回收率为98.5%,RSD为1.91%(n=5)。结论该方法简便,准确,专属性强,可用于该制剂的质量控制。OBJECTIVE To establish the quality standard for Yigan powder. METHODS Rhizoma Corydalis and Cortex Magnoliae Officinalis in the medicine were identified by TLC, the Tanshinone Ⅱ A content in this medicine was determined by HPLC.The methanol-water（75 ： 25）solulion was used as the mobile phase, the column was C18, the flow rate was 1.2mL·min^-1, and the detective wavelength was at 270nm. RESULTS Rhizoma Corydalis and Cortex Magnliae Officinalis could be indentified by TLC. Tanshinone ⅡA showed a good linear relationship at the range of 7.92μg·mL^- 1 - 79.2μg·mL^-1, r = 0. 9995. The average recovery was 98.5 %, and RSD was 1.91% （n = 5）. CONCLUSION The method is simple, reliable, accurate and can be applied to the quality control of the preparation.

关 键 词：益肝冲剂 延胡索 厚朴 丹参酮ⅡA 质量标准 

分 类 号：R927.2[医药卫生—药学]