不同措施阻断乙肝母婴传播效果分析  

Efficiency analysis on different measures of mother-to-child transmission-blocking of hepatitis B

作　　者：郭燕[1] 张玉[1] 刘建琼[1] 吴宇[1] 王存库[1] 杜玉开[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院,湖北武汉430030

出　　处：《中国妇幼保健》2009年第23期3207-3210,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金项目项目编号:30671791

摘　　要：目的:探讨不同措施阻断乙肝母婴传播的效果。方法:回顾性调查248对乙肝表面抗原(HBsAg)阳性孕产妇及其婴幼儿接受过的乙肝母婴传播阻断措施,根据措施的不同分组,比较影响阻断措施的因素和各阻断措施的效果。结果:孕产妇文化程度、家庭人均收入、丈夫职业、HbeAg阳性对乙肝母婴阻断措施的有影响(P<0.05);不同干预措施婴幼儿6个月后HBsAg阳性率、6个月内和6个月后HBsAb抗体率差异均有统计学意义(P<0.05)。联合组脐血HBV-DNA阳性率最低;婴幼儿出生6个月后HBsAg阳性率,儿童组和联合组低于疫苗组和孕妇组,出生后6个月内HBsAb阳性率和6个月后HBsAb阳性率孕妇组均为最高,其次为联合组。结论:母婴联合免疫阻断乙肝母婴传播效果优于其他措施。Objective ： To explore the protective effect of different measures of mother - to - child transmission - blocking of hepatitis B. Methods： The data of 248 HBsAg - positive pregnant women and their infants receiving mother - to - child transmission - blocking of hepatitis B were analyzed retrospectively. They were divided into four groups by different measures they chose. The effect factors and efficiency were compared. Results： The effect factors of mother - to - child transmission - blocking of hepatitis B were education level of pregnant women, family per capita income, husband＇s career and positive HBeAg （P 〈 0. 05 ） . There was significant difference in positive rates of HBsAg and HBsAb after 6 months and positive rate of HBsAb within 6 months between different groups （ P 〈 0. 05 ） . The positive rate of HBV - DNA of combined group was the lowest. For the infants after 6 months, the positive rates of HBsAg in children group and combined group were lower than those in vaccine group and pregnancy group ; the positive rate of HBsAb in pregnancy group was the highest, the secondary was combined group. Conclusion ： The efficacy of pregnant women in pregnancy combined with infants at birth and postnatal vaccinated with HBIG is superior to other measures.

关 键 词：乙肝 母婴传播 乙肝免疫球蛋白 联合免疫 

分 类 号：R17[医药卫生—妇幼卫生保健] R512.6[医药卫生—公共卫生与预防医学]