甲基苯丙胺染毒动物模型的建立与评价  

Establishment and Evaluation of Animal Model with Methamphetamine Poisoning

作　　者：徐静[1,2] 周晓莉 张浩[4] 邓冲[1] 张岩[1] 李桢[1] 

机构地区：[1]昆明医学院法医学院,云南昆明650031 [2]中国人民解放军107医院,山东烟台264002 [3]云南景谷县公安局交警大队,云南景谷666400 [4]云南省公安厅刑侦总队,云南昆明650228

出　　处：《法医学杂志》2009年第4期282-285,共4页Journal of Forensic Medicine

基　　金：国家自然科学基金项目(30660202);云南省科技厅国际合作项目(2006GH22)

摘　　要：苯丙胺类中枢兴奋剂是21世纪最广泛滥用的毒品。甲基苯丙胺(methamphetamine,MA)的中毒机理、精神依赖性、耐药性以及治疗药物的研发是当前研究的热点。MA中毒动物模型的建立是研究MA相关问题的基础。MA动物模型建立的规范化和标准化对以后MA的进一步研究奠定了实验基础。本文结合国内外关于MA中毒动物的文献资料,通过对MA急性、亚急性以及慢性中毒动物模型研究的论述,对造模原理、造模方法和评价标准进行了探讨,并指出建立以动物为主体的MA中毒模型来进行相关实验研究的必要性以及重要性。Amphetamine-type stimulants（ATS） is the most widespread narcotics in the 21^st century. The methamphetamine＇s intoxication mechanism, psychological dependence, drug resistance and therapeutic drug development are the hot spots in current research. Establishment of animal model with methamphetamine poisoning is the basic for the relative studies, the normalization and standardization of the animal model settles the foundation for methamphetamine＇s further research. This article reviews the animal model of methamphetamine poisoning in China and abroad, the brief history of the acute, subacute and chronic animal model of methamphetamine poisoning, as well as the principles and methods of the animal model establishment and its evaluation criteria. The necessity, significance and its scientific expansion of performing experimental research on the methamphetamine poisoning animal model are also discussed.

关 键 词：法医毒理学 甲基苯丙胺 综述[文献类型] 模型 动物 

分 类 号：DF795.1[医药卫生—法医学]