胎盘生长因子和白细胞介素-6在正常和老化胎盘组织中的表达及其相关性  

The expression of placenta growth factor and IL-6 in placentas with different gestational stages and aging placentas.

作　　者：王艳[1] 张丽红[1] 

机构地区：[1]哈尔滨医科大学附属第一医院妇产科,150001

出　　处：《中国综合临床》2009年第8期797-800,共4页Clinical Medicine of China

基　　金：黑龙江省政府博士后启动基金（LRB05-111）;黑龙江省普通高等学校青年学术骨干支持计划项目（1151G027）;黑龙江省青年科学基金（QC08C79）

摘　　要：目的探讨胎盘生长因子（PLGF）和IE-6在胎盘发育、老化过程中的变化及意义。方法采用免疫组化法检测正常妊娠早期、中期、晚期胎盘组织及老化胎盘组织中PLGF和IL-6的表达状况。结果妊娠早、中、晚期及胎盘老化组IL-6的阳性表达率分别为60．0％（6／10）、50．0％（3／6）、42．9％（6／14）及88．9％（8／9）。PLGF在妊娠早、中、晚期及老化胎盘组织表达的阳性率分别为60．0％（6／10）、100．O％（6／6）、100．0％（14／14）及55．6％（5／9）。PLGF的表达强度妊娠晚期组与早期组（Х^2=18．89）和胎盘老化组（Х^2=20．42）比较差异均有统计学意义（P均〈0．01）；IL-6胎盘老化组与晚期妊娠组比较差异有统计学意义（Х^2=9．47，P〈0．05）。妊娠早、中、晚期和胎盘老化组胎盘组织中PLGF与IL-6表达相关性均无统计学意义（Х^2分别为0．625、0、0和1．41，P均〉0．05）。结论胎盘老化时，PLGF的表达较正常晚期妊娠明显减少，提示滋养细胞合成及分泌PLGF的功能下降。胎盘老化时，胎盘中IL-6的表达较正常晚期妊娠组明显增多。提示PLGF和IL_6可能在胎盘老化过程中发挥重要作用。Objective To study the expression of placenta growth factor（PLGF） and IL-6 in placentas with different gestational period. Methods Immunohistochemistry method was used to examine the expression of PLGF and IL-6 in placentas of different normal gestational periods and aging placentas. Results The positive expression rates of IL-6 in the first , second and third trimester of pregnancy were 60.0% （ 6/10 ）, 50.0% （ 3/6 ）, 42.9% （6/14） and 88.9% （8/9）, and the positive expression rates of PLGF were 60.0% （6/10）, 100.0% （6/6）, 100.0% （14/14） and 55.6% （5/9） respectively. PLGF expression intensity was significantly different among the third trimester of pregnancy placentas ,the first trimester of pregnancy placentas （ Х^2 = 18.89） and the aging placentas （Х^2= 20.42 ） （ P 〈 0. O1 for each）. IL-6 was significantly different between aging placentas and third trimester of pregnancy placentas （ Х^2=9.47, P 〈 0. 05 ）. No statistical significance were found on expression of IL-6 and PLGF among the three trimesters and aging groups （Х^2 = 0. 625,0,0 and 1.41, respectively, P 〉 0.05 ）. Conclusions The decreasing expression of PLGF in aging placenta tissue illustrates that the PLGF synthesis and secretion is decreased by trophoblast cells but IL-6 expression is remarkably increased ,which may play an important role in the pathogenesis of placental senescence.

关 键 词：胎盘老化 胎盘生长因子 白细胞介素-6 

分 类 号：R714.244[医药卫生—妇产科学]