Synthesis and antitumor activity of novel podophyllotoxin derivatives  

作　　者：Ming Zhao Min Feng Shu Fang Bai Yuan Zhang Wen Chao Bi Hong Chen 

机构地区：[1]Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin 300162, China [2]Graduate School of Tianjin Medical University, Tianjin 300070, China [3]TianJin Key Laboratory for Biornarkers of Occupational and Environmental Hazard, 7qanjin 300162, China

出　　处：《Chinese Chemical Letters》2009年第8期901-904,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.30873363);the Great Program of Science Foundation of Tianjin(No.06YFJZJCO2700);Program of Science Foundation of Tianjin(No.08JCYBJC070000).

摘　　要：In order to find compounds with superior bioactivity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with alcohols through maleic acid and tested against K562 and K562/A02 using MTT assay in vitro. ？2009 Hong Chen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.In order to find compounds with superior bioactivity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with alcohols through maleic acid and tested against K562 and K562/A02 using MTT assay in vitro. ？2009 Hong Chen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关 键 词：Podophyllotoxin derivatives CHEMOSYNTHESIS Anfitumor Multidrug resistance 

分 类 号：TQ463.2[化学工程—制药化工] TQ463.5