Citrinal A,a novel tricyclic derivative of citrinin,from an algicolous fungus Penicillium sp.i-1-1  

作　　者：Tian Jiao Zhu Lin Du Peng Fei Hao Zhen Jian Lin Qian Qun Gu 

机构地区：[1]Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China

出　　处：《Chinese Chemical Letters》2009年第8期917-920,共4页中国化学快报（英文版）

基　　金：supported by the Shandong Province Naturfl Science Fund(No.Z2006C 1 3);The anfitumor assay was performed at the Shanghai Institute of Matena Medica,Chinese Academy of Sciences.

摘　　要：Citrinal A （1）, a novel tricyclic compound with a rare tetrahydro-2H-benzofuro[7-b] [ 1,4]dioxin-9（3H）-one skeleton, along with two known related compounds, citrinin （2） and 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran （3） were isolated from an algicolous fungus Penicillium sp. i-1-1. The structure and stereochemistry of 1 were determined by comprehensive spectral and biogenic analysis. Its cytotoxic effects on the A-549 and HL-60 cell lines were evaluated. ？2009 Qian Qun Gu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.Citrinal A （1）, a novel tricyclic compound with a rare tetrahydro-2H-benzofuro[7-b] [ 1,4]dioxin-9（3H）-one skeleton, along with two known related compounds, citrinin （2） and 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran （3） were isolated from an algicolous fungus Penicillium sp. i-1-1. The structure and stereochemistry of 1 were determined by comprehensive spectral and biogenic analysis. Its cytotoxic effects on the A-549 and HL-60 cell lines were evaluated. ？2009 Qian Qun Gu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关 键 词：Citrinal Algicolous fungus PENICILLIUM 

分 类 号：S436.461[农业科学—农业昆虫与害虫防治] TQ463[农业科学—植物保护]