脯氨酸肽酶检测对肺结核的诊断价值  

Diagnostic value of serum prolidase in patients with tuberculosis

作　　者：程大也[1] 孔虹[2] 

机构地区：[1]中国医科大学附属第一医院,110001 [2]中国医科大学盛京医院

出　　处：《山西医药杂志（上半月）》2009年第8期691-692,共2页Shanxi Medical Journal

基　　金：辽宁省教育厅2008年度高等学校科研项目基金(2008752)

摘　　要：目的研究血清脯氨酸肽酶(PLD)对肺结核的诊断价值。方法测定66例肺结核患者和86例非结核肺部疾病患者血清PLD水平,应用受试者工作特征曲线(ROC)进行评价。结果肺结核患者组血清PLD活性水平高于非结核肺部疾病患者组和健康对照组,差异有统计学意义(P<0.01)。血清PLD活性的ROC曲线下面积为0.925,血清PLD活性的最优截断点约为999 U/L,灵敏度和特异度为86.4%和85.1%。结论PLD活性检测对鉴别肺结核和其他肺部疾病有重要的诊断意义。Objective The study was designed to evaluate the diagnostic value of prolidase （PLD） in tuberculosis. Methods PLD activity in serum sample collected from 66 patients with tuberculosis, 86 patients with non-tuberculosis and 48 healthy controls were measured using ELISA method. Receiver operating characteristic curve （ROC） was used to evaluate diagnostic value of PLD activity. Results PLD activity in serum collected from tuberculosis group was higher than that in non-tuberculosis group and healthy control group. The differences were significant （P〈0. 01）. The area under ROC of PLD was 0. 925. The optimum cut-off value of PLD was 999U/L. Sensitivity and specificity was 86.4% and 85.1% respectively. Conclusion Serum PLD is a potent marker for the diagnosis of tuberculosis.

关 键 词：结核 肺 ROC曲线 脯氨酸肽酶 

分 类 号：R521[医药卫生—内科学]