2型糖尿病大血管病变与血清CRP、IL-6、TNF-α水平的变化  

Relations of macrovascular lesions of type 2 diabetes to levels of serum CRP,IL-6 and TNF-α

作　　者：王光余[1] 黄晓辉[1] 吴国平[1] 

机构地区：[1]海南医学院附属医院急诊内科,海南海口570102

出　　处：《海南医学院学报》2009年第9期1012-1013,1017,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020090130)~~

摘　　要：目的:探讨2型糖尿病(DM)及大血管病变患者血清CRP、IL-6、TNF-α水平的变化。方法:双抗体夹心ELISA法和特种蛋白分析仪检测2型糖尿病组(20例)、2型糖尿病大血管并发症组(20例)和正常对照组(20例)患者血清中CRP、IL-6、TNF-α水平的变化。结果:2型糖尿病及大血管并发症组血清IL-6、TNF-α及CRP的水平较正常对照组均有升高(P<0.01或P<0.05),大血管并发症组IL-6、TNF-α及CRP的水平较2型DM组也有升高(P<0.01或P<0.05)。结论:2型糖尿病可能是细胞因子CRP、IL-6、TNF-α介导的炎症反应,是一种免疫性疾病。Objective：To determine the relations of macrovascular lesions of type 2 diabetes to levels of serum CRP, IL-6 and TNF-α. Methods： Case-control study was designed for the study. Group A was consisted of 20 patients with type 2 diabetes, group B was consisted of 20 patients with macrovascular lesions due to type 2 diabetes, group C was consisted of 20 health subjects. Their levels of serum CRP, IL - 6, TNF-α were studied using double-antibody sandwich ELISA and biochemistry analysis system for special proteins. Results： Levels of serum IL-6, TNF-α and CRP of patients in group A and B were all higher than that in group C （P 〈0.01 or P 〈0.05）. Conclusion： Type 2 diabetes may be an immune and inflammatory disease mediated by cytokines CRP, IL-6, TNF-α.

关 键 词：糖尿病 非胰岛素依赖型 C反应蛋白 白细胞介素6 肿瘤坏死因子-Α 

分 类 号：R587.1[医药卫生—内分泌]