新型吡喹酮薄膜衣片治疗日本血吸虫病的副反应及疗效研究  

Efficacy and adverse effects of film coated praziquantel for treatment of schistosomiasis japonica

作　　者：许静[1] 郭家钢[1] 吴晓华[1] 曾小军 杨卫平[3] 杨光斌[4] 郑江[1] 周晓农[1] 

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所,上海200025 [2]江西省寄生虫病防治研究所 [3]安徽省血吸虫病防治研究所 [4]湖北省疾病预防控制中心

出　　处：《中华预防医学杂志》2009年第8期718-722,共5页Chinese Journal of Preventive Medicine

摘　　要：目的了解新型吡喹酮薄膜衣片治疗日本血吸虫病的副反应状况及治疗效果。方法在湖北、江西、安徽血吸虫病流行区选择6-65岁的常住居民进行问卷调查、间接血凝免疫诊断试剂筛查，血检阳性者进行改良加藤法检查以确诊。对血检阳性者及部分自愿服药的正常人共计509名给服吡喹酮并调查药物的味道，对460例服药前无副反应相关症状的化疗对象随访副反应情况，对104例粪检阳性者在化疗后3个月进行疗效考核。结果84．7％（144／170）的被调查者认为新型吡喹酮薄膜衣片没有味道或者很轻，而吡喹酮素片对照组有92．9％（315／339）的被调查者认为药物味道较重。在化疗后1～2h，新型吡喹酮薄膜衣片化疗组副反应率为20．30％（27／133），吡喹酮素片对照组副反应率为83．18％（272／327），两化疗组间副反应率具有统计学意义（χ^2=164．316，P〈0．05）。其中新型吡喹酮薄膜衣片化疗组在神经肌肉系统、消化系统、心血管系统的副反应率分别为15．79％（21／133）、9．77％（13／133）、2．26％（3／133），而吡喹酮素片对照组在神经肌肉系统、消化系统、心血管系统的副反应率分别为81．65％（267／327）、49．24％（161／327）、12．84％（42／327），3个系统的副反应率在两化疗组间均具有统计学意义（χ^2神经肌肉系统=175．188，χ^2消化系统=62．601，χ^2心血管系统=12．010，P值均〈0．05）；吡喹酮薄膜衣片化疗组、素片对照组过敏反应发生率分别为2．26％（3／133）、0．92％（3／327），两者之间无统计学意义（χ^2=1．315，P=0．235）。化疗后第2天吡喹酮薄膜衣片化疗组和素片对照组的副反应率分别下降为3．01％（4／133）、38．53％（126／327），两组间存在统计学意义（χ^2=58．852，P〈0．05）。在化疗后2周新型吡喹酮薄膜衣片化疗组、素片对照组的副�Objective To understand the adverse and curative effects of film coated praziquantel for treatment of schistosomiasis japonica. Methods A questionnaire survey was conducted among 6 to 65 years old inhabitants from epidemic areas of schistosomiasis japonica in Jiangxi, Anhui and Hubei provinces ,while indirect haemagglutination assay （IHA） was also administrated. The Serological positives were tested by Kato-Katz technique. A total of 509 habitants of serological positives and healthy persons were given praziquantel. 460 targets with no relative symptoms were followed up for adverse effect of drugs in one month and efficacy evaluation of praziquantel was carried out in 104 parasitological positives 3 months posttreatment. Results The 84.7% （144/170） individuals thought film coated tablets were no smell or onlywith little smell while 92. 9% （315/339 ） targets in control group fell that tablets smelled bad. The total side effect rates of film coated praziquantel group and control group in 1 - 2 hours post-treatment were 20. 30% （27/133） and 83. 18% （272/327） respectively. There was significantly different between two groups （χ^2 = 164. 316,P 〈 0. 05 ）. The adverse effect rates of film coated praziquantel group in neuromuscular system, digestive system and cardiovascular system were 15.79% （ 21/133 ）, 9. 77% （ 13/133 ）, 2. 26% （ 3/133 ） individually which were significantly lower than those of control groups with 81.65% （267/327） ,49. 24% （ 161/327 ）, 12. 84% （42/327） in corresponding systems （ χ^2neuromuscular system = 175.188, χ^2digestive sy = 62. 601, χ^2cardiovascular system = 12. 010 ,P 〈 0. 05 ）. And the adverse effect rate of allergic reaction of film coated group was no significant difference with control group （ 2. 26% （ 3/133 ） versus 0. 92% （ 3/327 ）, χ^2 = 1. 315, P = 0. 235）. One day after treatment, the adverse effect rate of film coated tablets of praziquantel decreased to 3.01% （4/133）, significantly lower than that of cont

关 键 词：日本血吸虫病 吡喹酮 剂型 改制药物 评价研究 

分 类 号：R532.21[医药卫生—内科学] R981.1[医药卫生—临床医学]