5-溴-2-羟基苯甲醇的不对称羟基保护  

Protection of Asymmetric Hydroxyl of 5-Bromo-2-hydroxyphenylmethanol

作　　者：郭利兵[1] 李江涛[1] 张海洋[1] 蒋卫鹏[1] 韩兆海 杨瑞娜[1] 

机构地区：[1]河南省科学院化学研究所,河南郑州450002 [2]濮阳惠成化工有限公司,河南濮阳457000

出　　处：《合成化学》2009年第4期500-502,共3页Chinese Journal of Synthetic Chemistry

基　　金：河南省科技创新杰出人才计划资助项目

摘　　要：采用分步法对5-溴-2-羟基苯甲醇中的不对称羟基进行了选择性保护。以2,3-二氢吡喃和氯甲醚为保护基,经两步反应得5-溴-2-甲醚氧基苯甲-2-(四氢吡喃)醚,其结构经1HNMR,IR和MS表征。Selective protection of the asymmetric hydroxyl of 5-bromo-2-hydroxyphenylmethanol was investigated by method of fractional steps. 5-Bromo-2-methoxylmethlbenzyl-2-（tetrahydropyran） ether was synthesized by a two-step reaction using 2,3-dihydropyran and ether chloride as a protecting group of hydroxyl. The structures were characterized by ^1H NMR, IR and MS.

关 键 词：羟基保护 苯甲醇 不对称 溴 选择性保护 氯甲醚 二氢吡喃 四氢吡喃 

分 类 号：O629.13[理学—有机化学] TQ243.4[理学—化学]