三种中成药中乌头生物碱飞行时间质谱分析  

Analysis of Aconitum alkaloids in three kinds of proprietary Chinese medicines by MALDI-TOF mass spectrometry

作　　者：王勇[1] 邓晓春[1] 夏博[1] 

机构地区：[1]深圳大学生命科学学院,深圳518060

出　　处：《深圳大学学报（理工版）》2009年第3期257-261,共5页Journal of Shenzhen University(Science and Engineering)

基　　金：深圳市科技计划资助项目(200528)

摘　　要：对风湿骨康片、骨刺消痛胶囊和消痛灵酊3种中成药中的乌头生物碱提取分离后,进行基质辅助激光解吸电离-飞行时间质谱和电喷雾-四极杆飞行时间串联质谱分析.发现在这3种中成药中含有双酯型生物碱、其水解产物单酯生物碱以及尼奥灵类生物碱等11种生物碱.苯甲酰中乌头原碱是前两类口服药中的主要生物碱成分,而消痛灵酊中则以次乌头碱为主.Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used for the analysis of the aconitum alkaloids in three kinds of proprietary Chinese medicines including Fengshi-Gutong-Pian （ FSGTP）, Guci-Xiaotong-Jiaonang （GCXTJN） and Shexiang-Zhuifeng-Gao （SXFSG）. As many as 11 kinds of aconitum al- kaloids including diester-diterpenoid alklaoids, monoester- diterpenoid alaklaoids and neoline-type alkaloids were detected in these Medicines. Benzoylmesaeonine is the main alkaloid component in FSGTP and GCXTJN, however, benzovlaconine and mesaconitine become the dominant alkaloids in SXFSG.

关 键 词：制草乌 制川乌 基质辅助液充解吸电离-飞行时间 乌头碱 生物碱 中药质谱法分析 

分 类 号：O657.63[理学—分析化学]