两种不同雾化吸入剂联合应用孟鲁司特改善重度COPD稳定期患者的作用  

Improvement of adding montelukast on stable patients with severe chronic obstructive pulmonary disease

作　　者：黄勇[1] 崔社怀[1] 李昆霖[1] 韩爱军[1] 王兴胜[1] 

机构地区：[1]第三军医大学大坪医院呼吸内科,重庆400042

出　　处：《重庆医学》2009年第15期1908-1909,1912,共3页Chongqing medicine

摘　　要：目的观察孟鲁司特与噻托溴铵或糖皮质激素/β2-受体激动剂合用对重度慢性阻塞性肺疾病稳定期患者的改善作用。方法32例重度慢性阻塞性肺疾病稳定期门诊患者在原吸入噻托溴铵或糖皮质激素/β2-受体激动剂的基础上加用孟鲁司特口服,随访6个月,比较肺功能参数、6min行走距离及圣.乔治呼吸问卷评分的变化。结果重度慢性阻塞性肺疾病稳定期患者孟鲁司特与噻托溴铵合用,虽然对肺功能参数无明显作用,但6min行走距离及圣.乔治呼吸问卷的各项评分均明显改善;而与糖皮质激素/β2-受体激动剂合用时也显著地改善了6min行走距离及圣.乔治呼吸问卷评分,尽管效果不及与噻托溴铵合用,但有11例患者(69%)减少了吸入激素的用量。结论在重度慢性阻塞性肺疾病稳定期患者,孟鲁司特与噻托溴铵或皮质激素/β2-受体激动剂合用,都有明显改善效果,与噻托溴铵合用时更明显。Objective To observe the improved effects of montelukast combined tiotropium bromide or glucocorticosteriod/beta- 2 receptor agonist on stable patients with severe chronic obstructive pulmonary disease. Methods Thirty-two stable outpatients with severe chronic obstructive pulmonary disease continued to inhale previous tiotropium bromide or glucocorticosteriod/beta-2 receptor agonist,added to take orally montelukast 10mg,quaque nocte. After 6-month followed-up visiting, the changes of lung function,6 min walking distance and St. George＇s Respiratory Questionnaire score were compared. Results After montelukast combined tiotropium bromide,lung function was not improved, but 6 min walking distance and all scores of St. George＇s Respiratory Questionnaire were improved obviously. After combination glucocortieosteriod/beta 2 receptor agonist, the corresponding parameters were also improved, but the amplitudes were lower than combination tiotropium bromide, however, 11 patients（69%） decreased the dosage of glucocorticosteriod inhalation. Conclusion It is worth trying that the stable patients with severe chronic obstructive pul- monary disease use montelukast combined tiotropium bromide or glucocortieosteriod/beta 2 receptor agonist.

关 键 词：孟鲁司特 慢性阻塞性肺疾病 

分 类 号：R563.9[医药卫生—呼吸系统]