口腔白斑及鳞状细胞癌中Podoplanin的表达及其与微淋巴管密度的关系  

Podoplanin expression in oral squamous cell carcinoma and leukoplakia and its correlation with lymph vessels density

作　　者：张钢[1] 郭竹玲[1] 高岩[1] 

机构地区：[1]北京大学口腔医学院·口腔医院口腔病理研究室,100081

出　　处：《中华口腔医学杂志》2009年第8期488-491,共4页Chinese Journal of Stomatology

摘　　要：目的探讨Podoplanin在口腔白斑和鳞状细胞癌上皮中的表达及其与微淋巴管密度的关系，为进一步明确Podoplanin在鳞状细胞癌发生中的作用提供依据。方法用免疫组织化学方法对40例口腔白斑、27例早期浸润癌、32例浸润癌和10例正常口腔黏膜中Podoplanin的表达进行研究，分析病变上皮中Podoplanin的表达差异及其与病变微淋巴管密度的关系。结果Podoplanin在病变上皮中的表达随着上皮增生程度的增加而逐渐增强。白斑中Podoplanin高表达病例18例（45％），早期浸润癌中Podoplanin高表达病例22例（81％）、浸润癌中Podoplanin高表达病例25例（78％），而正常口腔黏膜均不表达Podoplanin。在白斑和早期浸润癌病变上皮附近的微淋巴管密度与病变上皮中Podoplanin的表达强度呈正相关（P〈0．05），在浸润癌病变上皮中Podoplanin的表达与癌内微淋巴管密度呈正相关（P〈0．05）。结论Podoplanin在口腔癌前病变癌变的发生、癌组织的浸润及癌转移中可能起重要作用。Objective To investigate the expression of Podoplanin in lesional epithelia of oral leukoplakia and squamous cell carcinoma and its correlation with lymph vessels density. Methods The expression of Podoplanin in 40 cases of oral leukoplakia, 27 cases of early stage of squamous cell carcinoma and 32 cases of infiltrated stage of squamous cell carcinoma was examined by immunohistochemistry. Meanwhile, the correlation between podoplanin expression in lesional epithelia and its corresponding lymph vessels density was also analysed. Results Podoplanin expression in epithelia was increased with the exacerbated epithelial proliferation. High expression of Podoplanin in lesional epithelia accounted for 45% in oral leukoplakia, 81% and 78% in early and infiltrated stage of squamous cell carcinoma respectively. Moreover, the lymph vessels density was also increased with the enhanced expression of Podoplanin in oral leukoplakia and early stage of squamous cell carcinoma （ P 〈 0. 05 ）. Podoplanin expression in infiltrated stage of squamous cell carcinoma was positively correlated with the lymph vessels density （ P 〈 0. 05 ）. Conclusions Podoplanin expression in different proliferative oral epithelia may be related to oral carcinogenesis, invasion and metastasis.

关 键 词：白斑 口腔 癌 鳞状细胞 PODOPLANIN 淋巴管密度 

分 类 号：R686[医药卫生—骨科学]