血清抗线粒体抗体阳性患者20例临床及实验室指标分析  

Clinical and experimental analysis of 20 patients with anti-mitochondrial antibody positive

作　　者：卢秋维[1] 夏莉莉[1] 罗艳芳[1] 

机构地区：[1]广西壮族自治区人民医院检验科,南宁市530021

出　　处：《内科》2009年第4期517-519,共3页Internal Medicine

摘　　要：目的分析血清抗线粒体抗体(AMA)阳性患者的临床及实验室指标,探讨抗线粒体抗体的诊断价值。方法将AMA阳性患者20例,分为原发性胆汁性肝硬化(PBC)11例和非PBC9例,分析每组临床特点、抗核抗体、肝功能指标。结果20例AMA阳性患者具有相同的抗核抗体核型,即胞浆粗颗粒型,滴度为1∶320～1∶1000;PBC患者,ALP、γ-GT较ALT、AST显著增高,而并发其他自身免疫性疾病的PBC患者,临床特征不典型,临床不易诊断;9例非PBC患者中,肝病患者6例,其他无肝病患者3例。结论AMA在PBC患者中检出率极高,但AMA并不只出现在PBC患者血清中,在肝胆疾病、其他疾病患者血清中亦可检出。Objective To explore the diagnostic value of serum anti-mitochondrial antibody （AMA） by analyzing the clinical and experimental features. Methods 20 patients with AMA positive were divided into 11 cases of primary biliary cirrhosis （PBC）, 9 cases of non-PBC, the clinical manifestations ;anti-nuclear ahtibedies （ANA） and liver function were analyzed. Results All 20 patients were positive for ANA and showed granular cytoplasm patterns, the levels of titer were from 1 ： 320 to 1 ： 1000 ; The levels of alkaline phosphatase （ALP） and γ-glutamyltransferaso （GGT） were markedly higher than alanine aminofransferase （ALT）, aspartate aminotnmsferase （AST） in 11 PBC patients; while patients of PBC concomitant with other autoimmune disease were atypical and difficult to diagnose. Of 9 cases of non-PBC patients,6 were hepato-biliary patients and 3 were hepato-biliary free patients. Conclusions AMA detection is sensitive marker for the diagnosis of PBC ;AMA will be detected not only in PBC, but also in the bepato-biliary and the other disease.

关 键 词：抗线粒体抗体 抗核抗体 原发性胆汁型肝硬化 

分 类 号：R593.9[医药卫生—内科学] R446.6[医药卫生—临床医学]