匹罗卡品诱导的癎样放电大鼠EEG节律的同步分析  

Synchronization analysis of EEG rhythm from pilocarpine-induced epileptiform discharge rats

作　　者：刘衍素[1] 夏阳[2] 雷蕾[2] 赖永秀[2] 李金坤[2] 

机构地区：[1]四川省卫生学校教务科,四川成都610100 [2]电子科技大学生命科学与技术学院

出　　处：《临床神经电生理学杂志》2009年第4期195-198,共4页Journal of Clinical Electroneurophysiology

基　　金：国家自然科学基金项目（No.30570474,No.30870655）

摘　　要：目的：了解癎样放电不同阶段脑电信号各节律的同步关系及其在不同脑功能状态间转换时的变化。方法：用似然同步方法分析由匹罗卡品（pilocarpine）诱导的癎样放电大鼠的大脑皮层和海马的不同节律脑电信号。结果：在同一种脑功能状态下，左右皮层和左右海马脑电信号各节律的同步性之间存在显著差异。其中无癎样放电时，δ节律的同步性显著高于α，σ，β节律的同步性（P〈0．01）；连续性癎样放电时，δ节律的同步性显著低于θ，α节律的同步性（P〈0．05）。当脑功能状态从无癎样放电向连续性癎样放电转换时，不同脑区间脑电信号各节律的同步性显著增强（P〈0．01）；从连续性癎样放电向周期性癎样放电转换时，不同脑区间脑电信号除δ节律外，其余各节律的同步性显著降低（P〈0．05）。结论：大鼠在癎样放电前δ节律可能已先于其它节律产生了类似于癎样放电的同步现象；但在癎样放电过程中则是较高节律的同步化活动占优势；而在癎样放电终止过程中，δ节律始终维持在较高的同步状态，因而推测δ节律在痴样放电过程中可能起着重要的作用。Objective： To understand synchronized relation between rhythms in different shifted states. Methods： To analyse the changes of synchronization in different rhythms in ECoG and EEG from pilocarpine-induced epileptiform discharge rats by synchronized likelihood analysis. Results： In non-epileptilform discharge state, synchronization of delta rhythm was significantly higher than that of alpha, sigma and beta rhythms （P〈0. 01）;in continuous-epileptiform discharge, synchronizations of delta rhythm was significantly lower than that of theta and alpha rhythms （P〈0.05）. When brain state transfered from non-epileptiibrm discharge to continuous-epileptiform discharge, synchronizations of all rhythms were significantly strengthened （P〈0.01）. But when brain state transfered from continuousepileptiform discharges to period-epileptiform discharges, synchroriizations of all rhythms except delta were significantly weakened （P〈0. 05）. Conclusion： The synchronization phenomenon of delta rhythm, which was similar to epileptiform discharge, came into being before others; and strengthened synchronization of high frequent band signals acted as the leading role. during epileptiform discharge. Furthermore, delta rhythm always kept a high synchronization level during epileptiform discharge, it is speculated that delta rhythm might act as an important role in the process of epileptiform discharge.

关 键 词：癫癎 癎样放电 脑电节律 似然同步 

分 类 号：R971.7[医药卫生—药品] R742.1[医药卫生—药学]