乌司他丁对有机磷农药中毒的免疫保护研究  

Clinical study on the immune protection of ulinastatin in acute organophosphorus pesticides poi. soning （AOPP）

作　　者：关永东[1] 雷间红[1] 邓素贞[1] 陈洁文[1] 徐辉[1] 

机构地区：[1]暨南大学第五附属医院急救中心,广东清远 511500

出　　处：《中国急救医学》2009年第8期705-707,共3页Chinese Journal of Critical Care Medicine

基　　金：广东省卫生厅医学科研基金立项项目（No.82001125）

摘　　要：目的探讨乌司他丁（Ulinastatin，UTI）对急性有机磷农药中毒（AOPP）的免疫保护作用。方法45例重症AOPP患者随机分为Ⅰ组（UTI治疗组，n=23）和Ⅱ组（非UTI治疗组，n=22）。在急性期治疗前后分别测定肿瘤坏死因子-α（TNF—α）、血清细胞间黏附分子-1（ICAM—1）的水平变化，并以20例健康人为对照。结果Ⅰ组TNF—α和ICAM-1治疗前后比较差异均有统计学意义（P〈0．01），Ⅱ组治疗前后比较差异均无统计学意义（P〉0．05），两组治疗后比较差异均有统计学意义（P〈0．01）。结论UTI对AOPP患者在免疫领域中起治疗作用，其最主要机制可能是通过抑制两种关键性的免疫细胞因子TNF—α、ICAM—1对炎性介质的级联“瀑布”效应，终止它们对重要器官的进一步损害。Objective To investigate the protective effects of ulinastatin on acute organophosphorus pesticides poisoning （ AOPP）. Methods 45 patients of severe AOPP were randomly divided into ulinastatin intervention group （ group Ⅰ ） and non - ulinastatin intervention group （ group Ⅱ）. The changes of TNF - α and ICAM - 1 in whole blood of the groups before and after the treatment were compared. 20 healthy individuals were selected as control group. Results There were significant differences in TNF - α and ICAM - 1 levels before and after the treatment of group Ⅰ （ P 〈 0.01 ）. The results were opposite in group Ⅱ （ P 〉 0.05 ）. There were significant differences in TNF - etand ICAM - 1 levels between group Ⅰ and group Ⅱ （ P 〈 0. 01 ）. Conclusion Ulinastatin had immune protection on AOPP. It may protect major organs from the further injury by inhibiting the expression of TNF - etand ICAM - 1.

关 键 词：乌司他丁 肿瘤坏死因子-Α 血清细胞间黏附分子-1 急性有机磷农药中毒 

分 类 号：R595.4[医药卫生—内科学]