骨桥蛋白表达与人主动脉瘤发生的相关性  

Connection between osteopontin and human aneurysms

作　　者：聂斌[1] 周洪莲[1] 糜涛[1] 肖幸[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院综合医疗科,武汉430030

出　　处：《临床心血管病杂志》2009年第8期597-599,共3页Journal of Clinical Cardiology

基　　金：武汉市科技攻关计划项目(No:200862123565)

摘　　要：目的:研究骨桥蛋白在人胸主动脉瘤(TAA)和腹主动脉瘤(AAA)中的表达及其意义。方法:收集TAA标本13例、AAA标本20例以及正常主动脉标本6例,用免疫组织化学法检测其中骨桥蛋白的表达;并对其中的TAA标本8例、AAA标本10例及正常主动脉标本6例用Western blot法检测其中骨桥蛋白的表达。结果:在免疫组化实验和Western blot实验中,骨桥蛋白在TAA组和AAA组中均呈现阳性表达,而在正常对照组中为阴性,TAA组和AAA组与正常对照组比较差异有统计学意义(P<0.05),TAA组与AAA组之间的表达差异无统计学意义(P>0.05)。结论:骨桥蛋白与人TAA及AAA的发病之间存在着相关性。Objective：To investigate the expression and significance of osteopontin in human thoracic and abdominal aortic aneurysms. Method： Collect 13 cases of TAA, 20 cases of AAA and 6 cases of normal abdominal aortas,then detected the expression of osteopontin with immunobistochemical staining, And detected the expression of osteopontin in the 8 cases of TAA, 10 cases of AAA and 6 cases of normal abdominal aortas among them by Westernblot method. Result： In both immunohistochemical test and Westernblot test, osteopontin are greater in the TAA and AAA than in the normal abdominal aortas. The difference was statistically significant （P〈0.05）, but which was not between TAA and AAA（P〉0.05）. Conclusion： There are connection between osteopontin and human TAA and AAA.

关 键 词：主动脉瘤 骨桥蛋白 基质金属蛋白酶 平滑肌细胞 

分 类 号：R543.1[医药卫生—心血管疾病]