阿托伐他汀对急性ST段抬高型心肌梗死患者梗死相关血管自发再通率的影响  

Effect of atorvastatin pretreatment on the the incidence of spontaneous revascularization in the patients with ST elevated myocardia infarction

作　　者：王永亮[1] 陈淼[1] 李虹伟[1] 

机构地区：[1]首都医科大学附属北京友谊医院心血管中心,北京100050

出　　处：《临床心血管病杂志》2009年第8期606-608,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨阿托伐他汀对急性ST段抬高型心肌梗死(STEMI)患者梗死相关血管(IRA)再通的影响。方法:2007-05-2008-01,连续入选116例急性ST段抬高心肌梗死患者。年龄29～85岁,随机分为对照组和早期阿托伐他汀干预组(干预组,行急诊冠状动脉造影及介入治疗之前,口服80mg),随后行急诊冠状动脉造影,评价冠状动脉血管病变情况,冠状动脉IRA再通率和心肌梗死溶栓治疗临床试验(TIMI)血流情况。结果:60例对照组和56例干预组基础情况,包括性别、年龄、高血压、糖尿病、血脂、梗死前心绞痛病史等差异无统计学意义(P>0.05),2组间IRA和心肌梗死发病时间无差异(P>0.05)。IRA自发再通比例,在干预组明显高于对照组,前向TIMI血流亦存在显著差异(P=0.012)。结论:急性STEMI患者早期应用阿托伐他汀可提高IRA自发再通率及改善前向TIMI血流。Objective：To investigate the effect of atorvastatin on the incidence of spontaneous revascularization in the patients with ST elevated myocardial infarction. Method：The 116 patients with ST elevated myocardial infarction, aged from 29 to 85 years old,were randomized to pretreatment with atorvastatin （80-mg loading dose given a mean of 2 hours before cardioangiography[n= 56]） or placebo （n= 60）. TIMI grade and the incidence of spontaneous revascularization were determined. Result： At baseline, there were no difference in the age, sex, the history of angina peetoris, diabetes and hypertension between the statin group and control group（P〉0. 05）. An absolute difference of TIMI grade could be observed in the statin group; The incidence of spontaneous revaseularization of statin group was higher than that of control group （P= 0. 032 ）. Conclusions：Atorvastatin may elevate the incidence of spontaneous revaseularization in the patients with ST elevated myocardia infarction.

关 键 词：心肌梗死 阿托伐他汀 血管造影术 

分 类 号：R542.22[医药卫生—心血管疾病]