氧化异佛尔酮(3,5,5-三甲基环己烯-1,4-二酮)的合成研究  

Study on the Synthesis of 3,5,5 Trimethylcyclohexene 1,4 dione

作　　者：赵增国[1] 耿奎士[2] 

机构地区：[1]天津师范大学化学系 [2]天津商学院食品系

出　　处：《精细化工》1998年第4期42-45,共4页Fine Chemicals

摘　　要：用乙酰乙酸乙酯和异丙叉丙酮为原料合成了α异佛尔酮，再用格氏试剂法将α异佛尔酮转位成β异佛尔酮。然后在特殊的ＭｎⅡ或ＣｏⅡ携氧螯合催化剂作用下，再将其氧化为氧化异佛尔酮。该催化剂氧化效果良好，产率可达到６３％，用格氏试剂法合成β异佛尔酮比用乙二醇合成转化更彻底，产率可达７０％。α Isophorone was synthesized by the reaction of ethyl acetoacetate with isopropylideneacetone. Then α isophorone was deconjugated and converted to β isophorone with the Grignard reagent. Mn Ⅱ or Co Ⅱ complex as oxygen carrying catalyst,β isophorone was oxidated to the corresponding “enedione (3,5,5 trimethylcyclohexene 1,4 dione).The exeperimental results show that the catalyst effect achieves in 63% yield and the synthetic route of β isophorone by Grignard reagent is better in 70% yield.

关 键 词：异佛尔酮 氧化异佛尔酮 螯合剂 环化 

分 类 号：TQ224.5[化学工程—有机化工] O623.55[理学—有机化学]