胃炎饮对实验性胆汁反流性胃炎大鼠血浆6-酮-前列腺素F_(1α)和血栓素B_2的影响  

Effect of Weiyanyin on the content of substance P in mucosal of experiment bile reflux gastritis rats

作　　者：杨牧祥[1] 于文涛[1] 王长垠[2] 白瑞军 王少贤[1] 

机构地区：[1]河北医科大学中医学院中医诊断学教研室,河北石家庄050091 [2]邯郸市中医院内一科,河北邯郸056001 [3]廊坊经济技术开发区医院院办室,河北廊坊065001

出　　处：《中国中西医结合消化杂志》2009年第4期214-216,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：河北省中医药管理局科学研究计划项目(2007016)

摘　　要：[目的]探讨胃炎饮对实验性胆汁反流性胃炎大鼠血浆6-酮-前列腺素F1α(6-Keto-PGF1α)和血栓素B2(TXB2)水平的影响。[方法]采用自制反流液灌胃建立实验性胆汁反流性胃炎大鼠模型,以多潘立酮为对照,观察胃炎饮对大鼠胃黏膜病理组织学和血浆6-Keto-PGF1α、TXB2水平的影响。[结果]模型组大鼠胃黏膜出现明显破损、脱落,黏膜下可见大量炎细胞浸润,大部分大鼠胃黏膜可见不典型增生和肠上皮化生,同时血浆6-Keto-PGF1α水平明显下降,TXB2水平明显上升(P<0.01);与模型组比较,各治疗组均可明显改善大鼠胃黏膜病理组织学变化,升高6-Keto-PGF1α水平,降低TXB2水平(P<0.01,<0.05)。[结论]胃炎饮可调节血浆6-Keto-PGF1α和TXB2水平,提高胃黏膜血流量,加强胃黏膜的黏液-碳酸氢盐屏障,减轻反流液对胃黏膜的损伤。[Objective]To observe the effect of Weiyanyin on 6-Keto-prostaglandin-1α（6-Keto- PGF-1α） and thromboxane B-2（TXB-2）in blood plasma of experiment bile reflux gastritis rats. [Methods]The model of experiment bile reflux gastritis was made by drinking reflux liquid. Com- pared with Domperidone, the effect of Weiyanyin on Pathological histology, the 6-Keto-PGF-1α and TXB-2 in blood plasma of bile reflux gastritis rats were observed. [Results] The mucosa of rats in model group was damaged,amotic,and a lot of inflammatory cell cglandular organ hyperplasy and intestinal metaplasia ould be seen in most of rats; At the same time the content of the 6- Keto-PGF-1α were decreased and TXB-2 increased（P〈0. 01） ;Compared with model group, Weiyanyin could improve pathological histology of experiment bile reflux gastritis rats, increase the content of 6-Keto-PGF- 1α and decrease the content of TXB-2 （P〈 0. 01）. [Condasion] Weiyanyin can regulate the content of 6-Keto-PGF-1α and TXB-2, improve gastric mucosal blood flow and protect mucosal of experiment bile reflux gastritis rats effectively.

关 键 词：胃炎饮 胃炎 实验性胆汁反流性 6-酮-前列腺素F1Α 血栓素B2 

分 类 号：R544.1[医药卫生—心血管疾病] R259.733[医药卫生—内科学]