2型糖尿病合并高尿酸血症与代谢综合征的相关性研究  

Relationship between serum uric acid level and the metabolic syndrome in type 2 diabetes

作　　者：冯龄[1] 赵秀娥[1] 

机构地区：[1]上海市静安区中心医院,200040

出　　处：《临床内科杂志》2009年第8期548-550,共3页Journal of Clinical Internal Medicine

摘　　要：目的研究2型糖尿病患者血清尿酸水平在代谢综合征发病中的作用。方法将365例2型糖尿病患者按血清尿酸水平分成两组：高尿酸水平组77例，尿酸水平正常组288例，观察血清尿酸水平与代谢综合征主要组分的相关性。结果血尿酸与血压、甘油三酯、体质指数呈正相关（P〈0．01），与高密度脂蛋白胆固醇呈负相关（P〈0．01）；高尿酸组代谢综合征患病率为77．92％，尿酸正常组为51．04％（P〈0．01）。结论2型糖尿病患者血尿酸水平与年龄，收缩压，甘油三酯，低密度脂蛋白胆固醇及体质指数多因素相关，提示2型糖尿病高尿酸血症可能是代谢综合征发病的危险因素之一。Objective To study the effect of serum uric acid levels on the metabolic syndrome. Methods 365 patients with type 2 diabetes mellitus were divided into 2 groups according to their uric acid levels, and then the relationship between serum uric acid and the chief parameters of the metabolic syndrome were observed. Results There was a positive correlation between serum uric acid levels and blood pressure,triglycerides, body mass index（ P 〈 0.01 ）, and a negative correlation between serum uric acid levels and HDL-cholesterol（ P 〈 0.01 ）. Conclusion There were many factors related to serum uric acid levels in type 2 diabetic patients. It suggested that hyperuricemia might be one of the risk factors for metabolic syndrome.

关 键 词：2型糖尿病 尿酸 代谢综合征 

分 类 号：R587.1[医药卫生—内分泌]