胰腺癌外科治疗影响病人生存相关因素分析  

Survival analysis of relevant factors for surgical treatment of pancreatic cancer

作　　者：侯宝华[1] 区金锐[1] 

机构地区：[1]广东省医学科学院广东省人民医院肝胆胰外科,广东广州510080

出　　处：《中国实用外科杂志》2009年第8期659-661,共3页Chinese Journal of Practical Surgery

基　　金：广东省自然科学基金资助(7001209);广东省科技计划项目(2007B060401034)

摘　　要：目的探讨胰腺癌的手术方式、病理分期、淋巴结转移、血管侵犯对病人存活率、生存时间的影响。方法回顾性分析广东省人民医院1996年1月至2006年10月收治的50例胰腺癌病人随访资料。应用SPSS13.0统计软件包进行统计学分析。结果1、3、5年累计存活率63.0%,24.0%,12.0%,手术死亡率和术后总并发症发生率为4.0%和38.0%。COX回归分析手术方式和病理分期对生存时间及累计存活率的影响有统计学意义(P<0.05)。R0切除(根治性切除)组的中位生存时间和3、5年累计存活率分别为30个月、41.0%、20.0%,明显高于R1和R2切除组,差异具有统计学意义(P<0.05)。Ⅰ期病人3、5年累计存活率分别为49.0%、28.0%。结论早诊断、早治疗可以明显提高病人R0切除率、中位生存时间和存活率。R0切除仍是目前惟一有效、安全的治疗方法。Objectives To evaluate outcome of patients with pancreatic cancer under different surgical modalities,and to sum up the treatment experience for pancreatic cancer. Methods The follow-up data of 50 patients with pancreatic cancer between 1996 and 2006 were analyzed. SPSS 13.0 was performed to analyze the follow-up data. Results For 50 followed-up patients, 1, 3, 5 years cumulative survival rate is 63.0 %, 24.0%, 12.0%, respectively. Operative mortality is 4% and 38.0% of patients have complication after operation. Cox regress indicates that surgery modus and staging are significantly risk factor for cumulative survival rate （p〈0.05）. Median of survival time and 3,5 years cumulative survival rate of patients performed by R0 resection are 30 months, 41.0%, 20.0%, respectively, which higher than R 1 and R2 （p〈 0.05）. Three, five-year cumulative survival rate of patients with stage Ⅰ is 49.0% and 28.0%. Conclusion R0 resection is the only effective method to improve the rate of cumulative survival time.

关 键 词：胰腺肿瘤 随访 

分 类 号：R6[医药卫生—外科学]