老年高血压患者动脉僵硬度的影响因素  

Risk Factors for Arterial Stiffness in Elderly Patients with Essential Hypertension

作　　者：方向阳[1] 吴金玲[1] 牛红育[1] 陆玫[1] 刘淼冰[1] 

机构地区：[1]首都医科大学附属北京朝阳医院综合科,北京100020

出　　处：《中华高血压杂志》2009年第8期716-719,共4页Chinese Journal of Hypertension

基　　金：北京市保健专项资金科研课题(京06-05号)

摘　　要：目的探讨老年高血压患者动脉僵硬度的相关因素。方法选择老年高血压患者119例,平均年龄(75.6±7.0)岁,测定颈股动脉脉搏波传导速度(cfPWV)作为评价动脉僵硬度指标,以cfPWV>12m/s为标准,把所有患者分为2组,cfPWV>12m/s组,共70例,cfPWV≤12m/s组,共49例,患者行颈动脉超声检查评价颈动脉粥样斑块情况,并测量血压、糖化血红蛋白等指标,以cfPWV>12m/s为因变量,以颈动脉粥样斑块、血压、糖化血红蛋白等指标为自变量,行多因素Logistic回归分析。结果校正了体质量指数、性别、脑卒中、空腹血糖等因素后,影响cfPWV的因素有年龄、收缩压、脉压、冠心病、糖尿病、颈动脉粥样斑块、糖化血红蛋白,其中以年龄与收缩压危险度最大。结论老年高血压患者动脉僵硬度与年龄、收缩压、脉压、冠心病、糖尿病、颈动脉粥样斑块、糖化血红蛋白密切相关,其中以年龄与收缩压危险度最大。Objective To analysis risk factors related with arterial stiffness in elderly patients with essential hypertension. Methods A cohort of 119 elderly patients with essential hypertension were enrolled. Arterial stiffness was assessed by carotid-femoral pulse wave velocity（ cfPWV）. The patients were classified into 2 groups according to cfPWV （cfPWV〉12 m/s group, n=70; cfPWV≤12 m/s group, n：491. Carotid atheromatous plaque was assessed by Doppler echocardiograph; blood pressure and hemoglobin Alc were measured. Results After adjustment for body mass index （BMI）, sex, stroke and fasting blood glucose, logistic multivariable analysis showed that cfPWV associated with age, systolic blood pressure（SBP）, pulse pressure, coronary artery disease, diabetes, carotid atheromatous plaque and hemoglobin Alc. Conclusion Arterial stiffness in elderly patients with essential hypertension was strongly positively associated with age, SBP, pulse pressure, coronary artery disease, diabetes, carotid atheromatous plaque and hemoglobin Alc.

关 键 词：老年 高血压 动脉僵硬度 

分 类 号：R544.1[医药卫生—心血管疾病]