丙泊酚和咪唑安定用于重症监护室患者的观察  

Sedative effect of propofol and midazolam used in mechanical ventilation patients in the intensive care u-nit

作　　者：刘志强[1] 

机构地区：[1]郑州市第二人民医院麻醉科,450052

出　　处：《中国现代药物应用》2009年第15期40-41,共2页Chinese Journal of Modern Drug Application

摘　　要：目的观察丙泊酚和咪唑安定对ICU呼吸机治疗患者的镇静效果,为危重患者镇静用药提供依据。方法选择在ICU呼吸机治疗的患者40例,随机分为两组。丙泊酚组2l例,先静注丙泊酚1.5mg/kg镇静诱导,然后改用微量注射泵持续注射丙泊酚,根据Ramsay氏分级标准调整用量;咪唑安定组19例,先静注咪唑安定0.05mg/kg镇静诱导,然后改用微量注射泵持续注射咪唑安定,根据不同镇静分级调整用量。分别记录Ramsay氏分级Ⅲ～Ⅵ级时的用药量及用药前后、苏醒时的心率、血压、脉搏血氧饱和度和停药后苏醒时间,停药后再入睡和恶心发生情况。结果两组患者随镇静程度的加深而用药量增加,但呼吸、循环无明显抑制。丙泊酚组较咪唑安定组苏醒时间快,且苏醒后再入睡及出现恶心患者明显减少。结论丙泊酚和咪唑安定都能达到ICU患者所需的镇静要求。丙泊酚苏醒快,且苏醒后再入睡和恶心的发生明显少于咪唑安定。Objective To observe sedative effect of propofol and midazolam used in mechanically ventilating patients in the intensive care unit （icu）.Methods Fourty patiens with mechanical ventilationin ICU were randomly divided into two groups.The patients in propofol group were injected intravenously with propofol 1.5mg（kg as a loading dose.and infused continuously with a pump thereafter.The dose in-fused was adjusted according to Ramsay classification standard.The patients of midazolam group were in-jected intravenously with midazolam 01mg, kg as a loading dose,and infused continuously as in propofol group.The dosage,heart rate, blood pressure, arterial oxygen saturation before and after using the drugs andrecovery time were recorded when grade m-yi of Ramsay classification were reached.The recovery time after stopping infusion of the drugs as well as resleep and emesis were also recorded.Results The dosage of the two groups increased with the increase of sedation degree.The respiratory and circulation parameters were stable.The recovery time of propofol group was shorter than that of midazolam group.The number of patients sleeping again after recovery and emesis decreased obviously in propof01 group.Conclusion Both propofol and midazolam can reach the goal of sedation needed for ICU patients.Propofol can lcad to faster recovery after stopping the drug.The incidence of re-sleep after recovery and emesis is less when propofol is used for ICU patient＇S sedation.

关 键 词：重症监护 普鲁泊福 咪唑安定 

分 类 号：R614[医药卫生—麻醉学] R169.42[医药卫生—外科学]