血清淀粉样蛋白A与2型糖尿病肾病的相关性  

The association of the level of serum amyloid protein A and Diabetic Nephropathy in patient with type 2 diabetes mellintus

作　　者：胡礼仪[1] 王洪建[1] 张高明[1] 陈慧芹[2] 杨莉[1] 

机构地区：[1]江苏省沭阳县人民医院检验科,223600 [2]江苏省沭阳县人民医院内分泌科,223600

出　　处：《中国临床实用医学》2009年第8期46-48,共3页China Clinical Practical Medicine

摘　　要：目的探讨血清淀粉样蛋白A（serum amyloid A，SAA）水平在2型糖尿病（T2DM）伴发糖尿病肾病（DN）中的意义。方法根据尿白蛋白排泄率（UAER）将102例2型糖尿病（T2DM）患者分为单纯糖尿病组（SDM组）、早期糖尿病肾病组（EDN组）和临床糖尿病肾病组（CDN组），30名本院健康体检者作为对照组，应用免疫透射比浊法测定血清SAA，将组间的SAA进行统计学比较，并进行相关分析。结果各糖尿病组血清SAA水平与对照组比较均具有统计学差异（P〈0．05），EDN、CDN组显著高于SDM组（P〈0．05），CDN组与EDN组相比亦明显升高（P〈0．05）。相关分析显示SAA与UAER呈显著正相关（r=0．536，P〈0．01）。结论SAA水平在T2DM组和并发DN组中随着UAER的增加而升高，两者之间关系密切，提示炎症反应可能在DN的发病机制中起着重要的作用。Objective To assess the role of the inflammatory reaction in pathogenesis of diabetic nephropathy （DN） by analyzing the difference of serum amyloid A level in the serum between patients with DN and control group. Methods According to the results of urinary albumin excretion rate （ UAER）, 102 type 2 diabetic mellitus cases were divided into simple diabetic mellitus （ SDM）, early diabetic nephropathy （EDN） and clinical diabetic nephropathy （ CDN ） ; other 30 healthy persons were employed as controls. The levels of serum amyloid A of all groups were examined. Results There were significant difference of SAA level in all groups as compared with control group （ P 〈 0.05 ） , SAA level in EDN and CDN group were significantly higher than those in the SDM and control groups （P 〈 0. 05 ）, and those in CDN significantly higher than in EDN. And SAA were positively correlated in straight line with UAER （ r = 0. 536, P 〈 0.01 ）. Conclusion The levels of SAA in DN were increased with the increment of UAER. They had a close relationship. The inflammatory reaction may play an important role in the initiation and sustainment of diabetic nephropathy.

关 键 词：糖尿病肾病 血清淀粉样蛋白A 炎症反应 

分 类 号：R587.2[医药卫生—内分泌]