支气管哮喘患者呼气冷凝液中氮氧化物的意义  

The nitrigene oxids level in exhaled breath condensate of patients with asthma

作　　者：杜秀芳[1] 黄平[1] 冼美兰[1] 陈济明[2] 宋冰[2] 李志莹[2] 洪永忠[2] 杜冀辉[2] 

机构地区：[1]广东医学院附属深圳南山医院呼吸科,518052 [2]广东医学院附属深圳南山医院检验中心,518052

出　　处：《中国临床实用医学》2009年第8期60-61,共2页China Clinical Practical Medicine

摘　　要：目的探讨支气管哮喘（哮喘）患者呼气冷凝液（EBC）中氮氧化物与气道炎症的关系。方法哮喘患者急性发作期30例，缓解期13例，健康对照组30例，收集其EBC，用分光光度法检测EBC中NO2^-、NO3^-、总NO2^-／NO3^-浓度。结果哮喘急性发作期EBC中NO2^-（1．508±0．705）μmol／L显著高于健康对照组（0．605±0．299）μmol／L，（P〈0．01）；缓解期NO2^-（0．622±0．253）μmol／L较急性发作期显著下降（P〈0．01）。EBC中NO3^-、总NO2^-／NO3^-的浓度在急性发作期及缓解期变化均无显著性差异（P〉0．05）。结论EBC中NO2^-水平高低与哮喘病情变化有关，故可作为哮喘患者气道炎症反应的一项重要监测指标。Objective To investigate the relationship between nitrogen oxides of exhaled breath condensate （EBC） and the airway inflammation in patients with asthma. Methods Thirty patients with asthma exacerbation ,13asthma remission and 30 healthy controls performed EBC collection. NO2^-, NO3^-and total NO2^-/NO3^- in EBC were measured by the spectrophotometry. Results The level NO2^- （ 1. 508 ± 0. 705 ） μmol/L in EBC of asthma exacerbation group was significantly increased than that in control group （0. 605 ± 0. 299 ） μmol/L （P 〈 0. 01 ）. NO2-in EBC showed decreased significantly in remission groud than that in exacerbation groud （P 〈 0. 01 ）. The levels of NO3^- and total NO2^-/NO3^- were no significant difference in all groups. Conclusion These findings suggest that inflammation was characteristic in the airways of asthma patients. The levels of NO2^- in EBC are associated with the change of asthma and may prove to be useful inmonitoring of airway inflammation in asthma.

关 键 词：支气管哮喘 呼气冷凝液 氮氧化物 

分 类 号：R562.25[医药卫生—呼吸系统] R587.1[医药卫生—内科学]