白细胞介素1β在中耳胆脂瘤上皮的表达  

Significance of IL-1β in epithelium of cholesteatoma in auris media

作　　者：李江民[1] 刘兆辉[1] 安伟[1] 林世龙[1] 

机构地区：[1]遵义医学院附属医院,贵州遵义563003

出　　处：《中国现代医学杂志》2009年第13期2020-2021,共2页China Journal of Modern Medicine

基　　金：遵义医学院青年医师启动基金资助项目(No:2006-017)

摘　　要：目的探讨IL-1β在中耳胆脂瘤上皮组织中的表达。方法采用酶联免疫法测定胆脂瘤上皮组织匀浆液及正常外耳道皮肤组织匀浆液中IL-1β水平。结果在12例中耳胆脂瘤上皮及10例正常外耳道皮肤组织中,IL-1β的表达分别为(313.562±52.924)及(141.414±31.335)pg/mL(P<0.01)。结论IL-1β在中耳胆脂瘤上皮组织中存在高表达;IL-1β可能参与促进胆脂瘤上皮增生。[Objective] To investigate the expression of interleukin-1 beta（IL-1β） in eholesteatoma and to explore the possible roles of it in the formation and development of the middle ear cholesteatoma. [Methods] We used the ELISA method to examine the level of IL-1β in epithelium in patients with middle ear eholesteatoma and 10 normal controls. [Result] IL-1β was 313.562± 52.924, 141.414 ± 31.335 pg/mL in 12 patients with middle ear eholesteatoma and 10 normal controls. The IL-1β levels in epithelium in patients with middle ear eholesteatoma were signifieantly higher than those in normal skin（P〈0.01）. [Conclusions] High level of IL-1β is found in the epithelium of eholesteatoma. IL-1β play an important role in the formation and development of eholesteatoma.

关 键 词：白细胞介素-1Β 胆脂瘤 中耳炎 

分 类 号：R764.2[医药卫生—耳鼻咽喉科]