连翘酯苷在大鼠胃肠的吸收动力学研究  

Studies on the absorption kinetics of forsythiaside in rat stomach and intestine

作　　者：李雪[1] 蒋学华[1] 李芸霞[2] 王凌[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]成都中医药大学药学院,四川成都610031

出　　处：《华西药学杂志》2009年第4期369-371,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:3007093530271614)

摘　　要：目的考察连翘酯苷在大鼠胃、肠道内的吸收动力学特征。方法采用大鼠胃肠吸收模型,用HPLC测定胃、肠灌注液中连翘酯苷的浓度。结果连翘酯苷在大鼠胃、十二指肠、空肠、回肠及结肠中每小时吸收率分别为6.36%、8.38%、8.19%、9.10%、6.91%。结论连翘酯苷在大鼠胃肠道内无特定吸收部位,吸收呈线性动力学过程,吸收机理为被动扩散。OBJECTIVE To investigate the absorption kinetics of forsythiaside in rat stomach and intestine.METHODS The drug concentration by in situ perfusion in rats was determined by HPLC.RESULT The hourly absorption percentages of forsythiaside in stomach,duodesum,jejunum,ileum and colon were 6.36%,8.38%,8.19%,9.10% and 6.91%,respectively.CONCLUSION Forsythiaside has no specific absorption site in rat gastrointestinal tract.Drug absorption was a linear dynamics with facilitated diffusion mechanism.

关 键 词：连翘酯苷 原位灌注模型 吸收动力学 高效液相色谱法 

分 类 号：R917[医药卫生—药物分析学]